⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17696618 | 0.86 | SMN1; SMN2 (0.31) | — | |
| SCHEMBL22104691 | 0.84 | — | — | |
| SCHEMBL19220325 | 0.84 | — | — | |
| SCHEMBL17694234 | 0.83 | MGLL (0.30) | — | |
| SCHEMBL16153543 | 0.81 | RECQL (0.34) | — | |
| SCHEMBL8757607 | 0.80 | — | — | |
| SCHEMBL18726698 | 0.78 | PARL (0.35) | — | |
| SCHEMBL28437179 | 0.78 | RECQL (0.33) | — | |
| SCHEMBL28469683 | 0.78 | KMT2A (0.38) | — | |
| SCHEMBL17344122 | 0.78 | RECQL (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220202947-A1 | METHODS OF PREVENTING METHIONINE OXIDATION IN IMMUNOCONJUGATES | IMMUNOGEN, INC. | 2022-06-30 | — | — | US | disclosed |
| US-20190111147-A1 | METHODS OF PREVENTING METHIONINE OXIDATION IN IMMUNOCONJUGATES | IMMUNOGEN, INC. | 2019-04-18 | — | — | US | disclosed |
| US-20190031712-A1 | Use of a PVDF membrane to purify cell-binding agent cytotoxic agent conjugates | IMMUNOGEN, INC. | 2019-01-31 | — | — | US | disclosed |
| US-10035817-B2 | Method of purifying cell-binding agent-cytotoxic agent conjugates with a PVDF membrane | IMMUNOGEN, INC. (US) | 2018-07-31 | — | — | US | disclosed |
| US-20170106095-A1 | ANTIBODY DRUG CONJUGATES | NOVARTIS AG (CH) | 2017-04-20 | — | — | US | disclosed |