Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CSF1R | P07333 | 1/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.38 |
| ▸ | FLT1 | P17948 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.38 |
| ▸ | CDK8 | P49336 | 1/20 | 0.38 |
| ▸ | GSK3A | P49840 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.38 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.38 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | GRM1 | Q13255 | 5/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL18759421 | 0.92 | PDE10A (0.44) | PDE10AHPGDCSF1RFGFR1FLT1 | |
| Trifluoroacetic Acid SCHEMBL18759441 | 0.92 | PDE10A (0.44) | PDE10AHPGDCSF1RFGFR1FLT1 | |
| Trifluoroacetic Acid SCHEMBL18759412 | 0.92 | PDE10A (0.44) | PDE10AHPGDCSF1RFGFR1FLT1 | |
| Trifluoroacetic Acid SCHEMBL18759465 | 0.92 | PDE10A (0.44) | PDE10AHPGDCSF1RFGFR1FLT1 | |
| Trifluoroacetic Acid SCHEMBL18759418 | 0.92 | PDE10A (0.44) | PDE10AHPGDCSF1RFGFR1FLT1 | |
| Trifluoroacetic Acid SCHEMBL18759443 | 0.92 | PDE10A (0.44) | PDE10AKDRTP53GRM1SMN1; SMN2 | |
| SCHEMBL16047506 | 0.92 | GRM1 (0.41) | HPGDCSF1RFGFR1FLT1KDR | |
| Trifluoroacetic Acid SCHEMBL18759411 | 0.91 | BTK (0.46) | PDE10AKDRGABRA1GABRG2GABRB3 | |
| Trifluoroacetic Acid SCHEMBL16044130 | 0.91 | GPR35 (0.43) | PDE10AHPGDLMNA | |
| Trifluoroacetic Acid SCHEMBL18759406 | 0.91 | PDE10A (0.45) | PDE10AKDRLMNAGRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970328-B1 | NOVEL INHIBITOR COMPOUNDS OF PHOSPHODIESTERASE TYPE 10A | ABBVIE DEUTSCHLAND (DE) | 2017-04-26 | — | — | EP | disclosed |