SCHEMBL18760427

SCHEMBL18760427

C=Cc1cnc(-c2nc3cc(C(F)(F)F)cnc3n2C)c(SCC)c1

nearest known ligand 0.49

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
▸ POLB P06746 1/20 0.49
▸ CRHR1 P34998 1/20 0.30
▸ MEN1 O00255 2/20 0.30
▸ KMT2A Q03164 2/20 0.30
▸ NPC1 O15118 1/20 0.30
▸ ALDH1A1 P00352 1/20 0.30
▸ STAT3 P40763 1/20 0.30
▸ STAT1 P42224 1/20 0.30
▸ CASP3 P42574 1/20 0.30
▸ RAB9A P51151 1/20 0.30
▸ SENP8 Q96LD8 1/20 0.30
▸ SENP7 Q9BQF6 1/20 0.30
▸ SENP6 Q9GZR1 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29431598 0.91 POLB (0.52) POLBCRHR1MEN1KMT2ANPC1
SCHEMBL14677239 0.91 POLB (0.52) POLBCRHR1MEN1KMT2ANPC1
SCHEMBL25765995 0.90 POLB (0.48) POLB
SCHEMBL15868302 0.87 POLB (0.48) POLBCRHR1MEN1KMT2ANPC1
SCHEMBL23729027 0.86 POLB (0.48) POLBCRHR1MEN1KMT2ANPC1
SCHEMBL16376049 0.86 POLB (0.48) POLBCRHR1MEN1KMT2ANPC1
SCHEMBL14676535 0.86 POLB (0.48) POLBCRHR1MEN1KMT2ANPC1
SCHEMBL24067328 0.86 POLB (0.48) POLBCRHR1MEN1KMT2ANPC1
SCHEMBL17986660 0.86 POLB (0.48) POLBCRHR1MEN1KMT2ANPC1
SCHEMBL23971584 0.86 POLB (0.50) POLBCRHR1MEN1KMT2ANPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11787809-B2 Oxime group-containing condensed heterocyclic compound or salt thereof, agricultural and horticultural insecticide comprising the compound, and method for using the insecticide NIHON NOHYAKU CO., LTD. (JP) 2023-10-17 — — US disclosed
US-11787809-B2 Oxime group-containing condensed heterocyclic compound or salt thereof, agricultural and horticultural insecticide comprising the compound, and method for using the insecticide NIHON NOHYAKU CO., LTD. (JP) 2023-10-17 — — US disclosed
US-11787809-B2 Oxime group-containing condensed heterocyclic compound or salt thereof, agricultural and horticultural insecticide comprising the compound, and method for using the insecticide NIHON NOHYAKU CO., LTD. (JP) 2023-10-17 — — US disclosed
EP-3372595-B1 OXIME GROUP-CONTAINING CONDENSED HETEROCYCLIC COMPOUND OR SALTS THEREOF AND AGRICULTURAL AND HORTICULTURAL INSECTICIDE CONTAINING SAID COMPOUND, AND METHOD FOR USING SAME NIHON NOHYAKU CO LTD (JP) 2023-06-28 — — EP disclosed
EP-3372595-B1 OXIME GROUP-CONTAINING CONDENSED HETEROCYCLIC COMPOUND OR SALTS THEREOF AND AGRICULTURAL AND HORTICULTURAL INSECTICIDE CONTAINING SAID COMPOUND, AND METHOD FOR USING SAME NIHON NOHYAKU CO LTD (JP) 2023-06-28 — — EP disclosed
US-20210371424-A1 OXIME GROUP-CONTAINING CONDENSED HETEROCYCLIC COMPOUND OR SALT THEREOF, AGRICULTURAL AND HORTICULTURAL INSECTICIDE COMPRISING THE COMPOUND, AND METHOD FOR USING THE INSECTICIDE NIHON NOHYAKU CO., LTD. (JP) 2021-12-02 — — US disclosed
US-20210371424-A1 OXIME GROUP-CONTAINING CONDENSED HETEROCYCLIC COMPOUND OR SALT THEREOF, AGRICULTURAL AND HORTICULTURAL INSECTICIDE COMPRISING THE COMPOUND, AND METHOD FOR USING THE INSECTICIDE NIHON NOHYAKU CO., LTD. (JP) 2021-12-02 — — US disclosed
CN-109415357-B Condensed heterocyclic compound having hydrazone group or salt thereof, agricultural and horticultural insecticide containing the compound, and method for using the same 日本农药株式会社 2021-10-29 — — CN disclosed
EP-3508485-B1 HYDRAZONYL GROUP CONTAINING-CONDENSED HETEROCYCLIC COMPOUND OR SALT THEREOF, AGRICULTURAL AND HORTICULTURAL INSECTICIDE COMPRISING THE COMPOUND, AND METHOD FOR USING THE INSECTICIDE NIHON NOHYAKU CO LTD (JP) 2021-02-24 — — EP disclosed
EP-3508485-B1 HYDRAZONYL GROUP CONTAINING-CONDENSED HETEROCYCLIC COMPOUND OR SALT THEREOF, AGRICULTURAL AND HORTICULTURAL INSECTICIDE COMPRISING THE COMPOUND, AND METHOD FOR USING THE INSECTICIDE NIHON NOHYAKU CO LTD (JP) 2021-02-24 — — EP disclosed
US-10377754-B2 Hydrazonyl group-containing condensed heterocyclic compound or salt thereof, agricultural and horticultural insecticide comprising the compound, and method for using the insecticide NIHON NOHYAKU CO., LTD. (JP) 2019-08-13 — — US disclosed
US-10377754-B2 Hydrazonyl group-containing condensed heterocyclic compound or salt thereof, agricultural and horticultural insecticide comprising the compound, and method for using the insecticide NIHON NOHYAKU CO., LTD. (JP) 2019-08-13 — — US disclosed
EP-3508485-A1 FUSED HETEROCYCLIC COMPOUND HAVING HYDRAZONYL GROUP OR SALTS THEREOF, PESTICIDE FOR AGRICULTURAL AND HORTICULTURAL USE CONTAINING SAID COMPOUND, AND METHOD FOR USING SAME Nihon Nohyaku Co., Ltd. (JP) 2019-07-10 — — EP disclosed
EP-3508485-A1 FUSED HETEROCYCLIC COMPOUND HAVING HYDRAZONYL GROUP OR SALTS THEREOF, PESTICIDE FOR AGRICULTURAL AND HORTICULTURAL USE CONTAINING SAID COMPOUND, AND METHOD FOR USING SAME Nihon Nohyaku Co., Ltd. (JP) 2019-07-10 — — EP disclosed
US-20190177319-A1 HYDRAZONYL GROUP-CONTAINING CONDENSED HETEROCYCLIC COMPOUND OR SALT THEREOF, AGRICULTURAL AND HORTICULTURAL INSECTICIDE COMPRISING THE COMPOUND, AND METHOD FOR USING THE INSECTICIDE NIHON NOHYAKU CO., LTD. (JP) 2019-06-13 — — US disclosed
US-20190177319-A1 HYDRAZONYL GROUP-CONTAINING CONDENSED HETEROCYCLIC COMPOUND OR SALT THEREOF, AGRICULTURAL AND HORTICULTURAL INSECTICIDE COMPRISING THE COMPOUND, AND METHOD FOR USING THE INSECTICIDE NIHON NOHYAKU CO., LTD. (JP) 2019-06-13 — — US disclosed
EP-3372595-A1 OXIME GROUP-CONTAINING CONDENSED HETEROCYCLIC COMPOUND OR SALTS THEREOF AND AGRICULTURAL AND HORTICULTURAL INSECTICIDE CONTAINING SAID COMPOUND, AND METHOD FOR USING SAME Nihon Nohyaku Co., Ltd. (JP) 2018-09-12 — — EP disclosed
WO-2017065183-A1 OXIME GROUP-CONTAINING CONDENSED HETEROCYCLIC COMPOUND OR SALTS THEREOF AND AGRICULTURAL AND HORTICULTURAL INSECTICIDE CONTAINING SAID COMPOUND, AND METHOD FOR USING SAME 日本農薬株式会社 2017-04-20 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210371424-A1 OXIME GROUP-CONTAINING CONDENSED HETEROCYCLIC COMPOUND OR SALT THEREOF, AGRICULTURAL AND HORTICULTURAL INSECTICIDE COMPRISING THE COMPOUND, AND METHOD FOR USING THE INSECTICIDE DDT, OXSR1, ODC1 POLB 3475/4885CRHR1 2088/4885MEN1 1624/4885
US-11787809-B2 Oxime group-containing condensed heterocyclic compound or salt thereof, agricultural and horticultural insecticide comprising the compound, and method for using the insecticide DDT, OXSR1, ODC1 POLB 3475/4885CRHR1 2088/4885MEN1 1624/4885
US-10377754-B2 Hydrazonyl group-containing condensed heterocyclic compound or salt thereof, agricultural and horticultural insecticide comprising the compound, and method for using the insecticide HCN1, HDHD5, H1-0 POLB 4231/4885CRHR1 1565/4885MEN1 817/4885
US-20190177319-A1 HYDRAZONYL GROUP-CONTAINING CONDENSED HETEROCYCLIC COMPOUND OR SALT THEREOF, AGRICULTURAL AND HORTICULTURAL INSECTICIDE COMPRISING THE COMPOUND, AND METHOD FOR USING THE INSECTICIDE HCN1, HDHD5, H1-0 POLB 4231/4885CRHR1 1565/4885MEN1 817/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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