SCHEMBL18762145

SCHEMBL18762145

O=S(=O)(O)c1cc(C(c2ccc(Cl)cc2)(C(F)(F)F)C(F)(F)F)ccc1Cl

nearest known ligand 0.44

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
HSD11B1 P28845 11/20 0.44
MCL1 Q07820 1/20 0.42
TSHR P16473 2/20 0.40
MEN1 O00255 1/20 0.40
ALDH1A1 P00352 1/20 0.40
KMT2A Q03164 1/20 0.40
ATM Q13315 1/20 0.40
L3MBTL1 Q9Y468 1/20 0.40
ESR1 P03372 1/20 0.38
ESR2 Q92731 1/20 0.38
CYP1A2 P05177 1/20 0.38
CYP3A4 P08684 1/20 0.38
MAPT P10636 1/20 0.38
TDP1 Q9NUW8 1/20 0.38
CNR2 P34972 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13278128 0.84 MCL1 (0.41) HSD11B1MCL1TSHRMEN1ALDH1A1
SCHEMBL27855804 0.80 ALDH1A1 (0.58) HSD11B1MCL1TSHRMEN1ALDH1A1
SCHEMBL13353950 0.76 HSD17B10 (0.46) HSD11B1MEN1ALDH1A1KMT2AESR1
SCHEMBL198460 0.74 MCL1 (0.53) MCL1TSHRALDH1A1L3MBTL1CYP3A4
SCHEMBL29384019 0.74 MCL1 (0.53) MCL1TSHRALDH1A1L3MBTL1CYP3A4
SCHEMBL608968 0.74 ESR1 (0.56) TSHRMEN1KMT2AESR1ESR2
Hydrochloric Acid SCHEMBL11157085 0.73 ALDH1A1 (0.52) MCL1TSHRALDH1A1L3MBTL1CYP3A4
SCHEMBL3695138 0.73 ALDH1A1 (0.52) MCL1TSHRALDH1A1L3MBTL1CYP3A4
SCHEMBL5078515 0.73 ALDH1A1 (0.52) MCL1TSHRALDH1A1L3MBTL1CYP3A4
SCHEMBL3009009 0.73 ALDH1A1 (0.52) MCL1TSHRALDH1A1L3MBTL1CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3365168-B1 LIGHTWEIGHT FLAME RETARDANT THERMOPLASTIC STRUCTURES SCHNELLER LLC (US) 2021-06-30 EP claimed
EP-3365168-A1 LIGHTWEIGHT FLAME RETARDANT THERMOPLASTIC STRUCTURES Schneller, LLC (US) 2018-08-29 EP claimed
WO-2017070276-A1 LIGHTWEIGHT FLAME RETARDANT THERMOPLASTIC STRUCTURES SCHNELLER LLC (US) 2017-04-27 WO claimed
US-20170113445-A1 LIGHTWEIGHT FLAME RETARDANT THERMOPLASTIC STRUCTURES SCHNELLER LLC 2017-04-27 US claimed