Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | TKT | P29401 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
| ▸ | RXRA | P19793 | 1/20 | 0.41 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11982021 | 0.86 | SMN1; SMN2 (0.49) | SMN1; SMN2ALDH1A1MAPTLMNAMAPK1 | |
| SCHEMBL11014329 | 0.85 | RAB9A (0.44) | SMN1; SMN2ALDH1A1MAPTNPC1RAB9A | |
| SCHEMBL28035552 | 0.85 | TKT (0.41) | SMN1; SMN2ALDH1A1MAPTLMNAMAPK1 | |
| SCHEMBL18764349 | 0.84 | RAB9A (0.43) | SMN1; SMN2ALDH1A1MAPTLMNAATM | |
| SCHEMBL10490466 | 0.81 | KMT2A (0.42) | SMN1; SMN2ALDH1A1MAPTLMNAMAPK1 | |
| SCHEMBL120535 | 0.81 | TKT (0.46) | SMN1; SMN2ALDH1A1MAPTLMNAMAPK1 | |
| SCHEMBL11018925 | 0.80 | RAB9A (0.57) | SMN1; SMN2ALDH1A1MAPTATMNPC1 | |
| SCHEMBL12775821 | 0.79 | KMT2A (0.41) | SMN1; SMN2ALDH1A1MAPTLMNAMAPK1 | |
| SCHEMBL11017065 | 0.78 | RAB9A (0.48) | SMN1; SMN2ALDH1A1MAPTLMNAMAPK1 | |
| SCHEMBL6850660 | 0.78 | SMN1; SMN2 (0.42) | SMN1; SMN2ALDH1A1MAPTLMNAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3365329-A1 | NURR1:RXR ACTIVATING COMPOUNDS FOR SIMULTANEOUS TREATMENT OF SYMPTOMS AND PATHOLOGY OF PARKINSON'S DISEASE | Vassilatis, Demetrios K. (GR) | 2018-08-29 | — | — | EP | disclosed |
| WO-2017068070-A1 | NURR1:RXR ACTIVATING COMPOUNDS FOR SIMULTANEOUS TREATMENT OF SYMPTOMS AND PATHOLOGY OF PARKINSON'S DISEASE | VASSILATIS DEMETRIOS K (GR) | 2017-04-27 | — | — | WO | disclosed |