Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 13/20 | 0.50 |
| ▸ | TLR7 | Q9NYK1 | 4/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA4 | P22748 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12619274 | 0.86 | TLR8 (0.65) | TLR8TLR7 | |
| SCHEMBL18772121 | 0.86 | TLR8 (0.52) | TLR8TLR7HSD17B10ALDH1A1 | |
| SCHEMBL18772107 | 0.81 | TLR8 (0.50) | TLR8TLR7 | |
| SCHEMBL18772042 | 0.81 | TLR8 (0.49) | TLR8TLR7ALDH1A1 | |
| SCHEMBL18771925 | 0.80 | TLR8 (0.45) | TLR8TLR7 | |
| SCHEMBL18772144 | 0.79 | TLR8 (0.45) | TLR8TLR7 | |
| SCHEMBL18772040 | 0.79 | TLR8 (0.45) | TLR8TLR7 | |
| SCHEMBL19265669 | 0.77 | TLR8 (0.49) | TLR8TLR7LMNAHSD17B10RAB9A | |
| SCHEMBL18772117 | 0.74 | KDM4E (0.39) | TLR8TLR7LMNAKDM4ECASP1 | |
| SCHEMBL18772025 | 0.73 | TLR8 (0.51) | TLR8TLR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3159337-A2 | SUBSTITUTED BENZOAZEPINES AS TOLL-LIKE RECEPTOR MODULATORS | Ventirx Pharmaceuticals, Inc. (US) | 2017-04-26 | — | — | EP | disclosed |