Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 9/20 | 0.49 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.49 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
| ▸ | PPARA | Q07869 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15496644 | 0.86 | TLR8 (0.64) | TLR8TLR7JAK2JAK3 | |
| SCHEMBL19265485 | 0.82 | TLR8 (0.49) | TLR8TLR7SMN1; SMN2MAPK1ALDH1A1 | |
| SCHEMBL18771832 | 0.81 | TLR8 (0.54) | TLR8TLR7 | |
| SCHEMBL19265665 | 0.81 | TLR8 (0.37) | TLR8TLR7JAK2MAPTALDH1A1 | |
| SCHEMBL18772121 | 0.80 | TLR8 (0.52) | TLR8TLR7ALDH1A1HPGDHSD17B10 | |
| SCHEMBL18772200 | 0.77 | TLR8 (0.50) | TLR8TLR7SMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL18772107 | 0.77 | TLR8 (0.50) | TLR8TLR7 | |
| SCHEMBL10345313 | 0.77 | TLR8 (0.67) | TLR8TLR7MAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL18772071 | 0.77 | TLR8 (0.46) | TLR8TLR7MAPTSMN1; SMN2MAPK1 | |
| SCHEMBL18772042 | 0.77 | TLR8 (0.49) | TLR8TLR7MAPTALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3208263-A1 | SUBSTITUTED BENZOAZEPINES AS TOLL-LIKE RECEPTOR MODULATORS | VentiRx Pharmaceuticals, Inc. (US) | 2017-08-23 | — | — | EP | disclosed |