Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.60 |
| ▸ | HPGD | P15428 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.55 |
| ▸ | TMEM97 | Q5BJF2 | 3/20 | 0.55 |
| ▸ | FYN | P06241 | 1/20 | 0.53 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.51 |
| ▸ | NAMPT | P43490 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26210939 | 0.91 | SMN1; SMN2 (0.55) | SMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL24849909 | 0.88 | HPGD (0.57) | SMN1; SMN2HPGDMEN1KMT2AKDM4E | |
| SCHEMBL31245842 | 0.88 | HPGD (0.57) | SMN1; SMN2HPGDMEN1KMT2AKDM4E | |
| SCHEMBL12629216 | 0.86 | SIGMAR1 (0.57) | SMN1; SMN2SIGMAR1TMEM97 | |
| SCHEMBL18773532 | 0.86 | SMN1; SMN2 (0.62) | SMN1; SMN2SIGMAR1TMEM97L3MBTL1 | |
| SCHEMBL2120631 | 0.86 | HPGD (0.68) | SMN1; SMN2HPGDMEN1KMT2AKDM4E | |
| SCHEMBL842218 | 0.85 | NPC1 (0.59) | SMN1; SMN2HPGDMEN1KMT2AKDM4E | |
| SCHEMBL12094830 | 0.85 | SIGMAR1 (0.56) | SMN1; SMN2KDM4ESIGMAR1TMEM97 | |
| SCHEMBL9491823 | 0.84 | SMN1; SMN2 (0.67) | SMN1; SMN2NAMPTL3MBTL1 | |
| SCHEMBL1909677 | 0.84 | KDM4E (0.55) | SMN1; SMN2HPGDMEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9630950-B2 | Inhibitors for steroid response elements and RNA polymerase II and related methods | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2017-04-25 | — | — | US | disclosed |