Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.67 |
| ▸ | MEN1 | O00255 | 3/20 | 0.67 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | HSD17B2 | P37059 | 4/20 | 0.53 |
| ▸ | HSD17B1 | P14061 | 3/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.51 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.51 |
| ▸ | LIMK2 | P53671 | 2/20 | 0.51 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.51 |
| ▸ | MMP13 | P45452 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2228587 | 0.91 | KMT2A (0.82) | KMT2AMEN1HPGDTDP1HSD17B2 | |
| SCHEMBL18773928 | 0.90 | KMT2A (0.62) | KMT2AMEN1HPGDTDP1HSD17B2 | |
| SCHEMBL18773897 | 0.89 | KMT2A (0.69) | KMT2AMEN1HPGDTDP1HSD17B2 | |
| SCHEMBL18773942 | 0.87 | KMT2A (0.84) | KMT2AMEN1HPGDHSD17B2HSP90AA1 | |
| SCHEMBL18773998 | 0.87 | MEN1 (0.61) | KMT2AMEN1HPGDTDP1HSD17B2 | |
| SCHEMBL15676751 | 0.87 | KMT2A (0.66) | KMT2AMEN1HPGDHSD17B2HSD17B1 | |
| SCHEMBL18774018 | 0.86 | KMT2A (0.59) | KMT2AMEN1HPGDTDP1HSD17B2 | |
| SCHEMBL18773985 | 0.84 | KMT2A (0.58) | KMT2AMEN1HPGDTDP1HSD17B2 | |
| SCHEMBL10268085 | 0.84 | KMT2A (0.62) | KMT2AMEN1HPGDHSD17B2HSD17B1 | |
| SCHEMBL1691687 | 0.83 | KMT2A (0.61) | KMT2AMEN1HPGDHSD17B2HSD17B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1773786-B1 | FIVE-MEMBERED HETEROCYCLES USEFUL AS SERINE PROTEASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2017-04-26 | — | — | EP | disclosed |