Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.58 |
| ▸ | MEN1 | O00255 | 3/20 | 0.58 |
| ▸ | HSD17B2 | P37059 | 4/20 | 0.51 |
| ▸ | HSD17B1 | P14061 | 3/20 | 0.51 |
| ▸ | PDK1 | Q15118 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.46 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | CDK4 | P11802 | 1/20 | 0.46 |
| ▸ | CCND1 | P24385 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18773897 | 0.86 | KMT2A (0.69) | KMT2AMEN1HSD17B2HSD17B1HPGD | |
| SCHEMBL15676761 | 0.85 | KMT2A (0.61) | KMT2AMEN1HSD17B2HSD17B1PDK1 | |
| SCHEMBL2228587 | 0.84 | KMT2A (0.82) | KMT2AMEN1HSD17B2HSD17B1L3MBTL1 | |
| SCHEMBL18773850 | 0.84 | KMT2A (0.67) | KMT2AMEN1HSD17B2HSD17B1RAB9A | |
| SCHEMBL18773900 | 0.84 | MEN1 (0.43) | KMT2AMEN1HSD17B2HSD17B1PDK1 | |
| SCHEMBL1696947 | 0.83 | KMT2A (0.58) | KMT2AMEN1HSD17B2HSD17B1PDK1 | |
| SCHEMBL1691800 | 0.82 | KMT2A (0.57) | KMT2AMEN1HSD17B2HSD17B1PDK1 | |
| SCHEMBL18970320 | 0.82 | KMT2A (0.57) | KMT2AMEN1HSD17B2HSD17B1PDK1 | |
| SCHEMBL18773942 | 0.81 | KMT2A (0.84) | KMT2AMEN1HSD17B2PDK1NPC1 | |
| SCHEMBL18773928 | 0.81 | KMT2A (0.62) | KMT2AMEN1HSD17B2HSD17B1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1773786-B1 | FIVE-MEMBERED HETEROCYCLES USEFUL AS SERINE PROTEASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2017-04-26 | — | — | EP | disclosed |