Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.69 |
| ▸ | MEN1 | O00255 | 2/20 | 0.69 |
| ▸ | HSD17B2 | P37059 | 7/20 | 0.61 |
| ▸ | HSD17B1 | P14061 | 5/20 | 0.61 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 4/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.52 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | CDK4 | P11802 | 1/20 | 0.48 |
| ▸ | CCND1 | P24385 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2228587 | 0.92 | KMT2A (0.82) | KMT2AMEN1HSD17B2HSD17B1HPGD | |
| SCHEMBL18773963 | 0.90 | MEN1 (0.60) | KMT2AMEN1HSD17B2HSD17B1HSP90AA1 | |
| SCHEMBL18773850 | 0.89 | KMT2A (0.67) | KMT2AMEN1HSD17B2HSD17B1HSP90AA1 | |
| SCHEMBL18773985 | 0.86 | KMT2A (0.58) | KMT2AMEN1HSD17B2HSD17B1HSP90AA1 | |
| SCHEMBL18773928 | 0.85 | KMT2A (0.62) | KMT2AMEN1HSD17B2HSD17B1HPGD | |
| SCHEMBL15645684 | 0.85 | HSD17B2 (0.56) | KMT2AMEN1HSD17B2HSD17B1HSP90AA1 | |
| SCHEMBL18773998 | 0.85 | MEN1 (0.61) | KMT2AMEN1HSD17B2HSD17B1HPGD | |
| SCHEMBL11913144 | 0.83 | HPGD (0.74) | KMT2AMEN1HSD17B2HSD17B1HPGD | |
| SCHEMBL18773942 | 0.83 | KMT2A (0.84) | KMT2AMEN1HSD17B2HSP90AA1HPGD | |
| SCHEMBL18774018 | 0.82 | KMT2A (0.59) | KMT2AMEN1HSD17B2HSD17B1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1773786-B1 | FIVE-MEMBERED HETEROCYCLES USEFUL AS SERINE PROTEASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2017-04-26 | — | — | EP | disclosed |