Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLA | P06280 | 2/20 | 0.55 |
| ▸ | GAA | P10253 | 2/20 | 0.55 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.55 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.55 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.55 |
| ▸ | MMP1 | P03956 | 1/20 | 0.55 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.55 |
| ▸ | ACHE | P22303 | 1/20 | 0.55 |
| ▸ | SLC47A2 | Q86VL8 | 1/20 | 0.55 |
| ▸ | SLC47A1 | Q96FL8 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.54 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18774809 | 1.00 | GLA (0.55) | GLAGAASLC22A2SLC22A1SLC22A3 | |
| SCHEMBL20807126 | 1.00 | GLA (0.55) | GLAGAASLC22A2SLC22A1SLC22A3 | |
| SCHEMBL24062777 | 0.96 | GLA (0.54) | GLAGAASLC22A2SLC22A1SLC22A3 | |
| SCHEMBL20807092 | 0.94 | GLA (0.55) | GLAGAASLC22A2SLC22A1SLC22A3 | |
| SCHEMBL18774814 | 0.93 | TOP1 (0.54) | GLAGAASLC22A2SLC22A1SLC22A3 | |
| SCHEMBL18774811 | 0.93 | TOP1 (0.54) | GLAGAASLC22A2SLC22A1SLC22A3 | |
| SCHEMBL18774812 | 0.91 | TOP1 (0.52) | GLAGAASLC22A2SLC22A1SLC22A3 | |
| SCHEMBL18782739 | 0.91 | TOP1 (0.52) | GLAGAASLC22A2SLC22A1SLC22A3 | |
| SCHEMBL18774813 | 0.90 | HDAC3 (0.46) | CYP3A4LMNATOP1HDAC3HDAC1 | |
| SCHEMBL24062788 | 0.89 | TOP1 (0.53) | GLAGAASLC22A2SLC22A1SLC22A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170114076-A1 | PODOPHYLLOTOXIN DERIVATIVES AND THEIR USE | DIGNITY HEALTH | 2017-04-27 | — | — | US | disclosed |
| US-20170114076-A1 | PODOPHYLLOTOXIN DERIVATIVES AND THEIR USE | DIGNITY HEALTH | 2017-04-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170114076-A1 | PODOPHYLLOTOXIN DERIVATIVES AND THEIR USE | CASP7, CASP3, PTMA | GLA 620/4885GAA 2672/4885SLC22A2 4062/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.