Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPR | P35270 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | XDH | P47989 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 2/20 | 0.39 |
| ▸ | MET | P08581 | 1/20 | 0.39 |
| ▸ | MOGAT2 | Q3SYC2 | 1/20 | 0.39 |
| ▸ | HTR1E | P28566 | 1/20 | 0.39 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.39 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.39 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18778944 | 0.99 | NPC1 (0.42) | SPRNPC1RAB9AEPHX1MAPK14 | |
| SCHEMBL18778954 | 0.93 | MET (0.43) | NPC1RAB9AMAPK14MAPTTP53 | |
| SCHEMBL18762662 | 0.92 | NPC1 (0.46) | NPC1RAB9AEPHX1MAPK14MAPT | |
| SCHEMBL18762667 | 0.90 | MAPT (0.46) | NPC1RAB9AMAPTTP53SMN1; SMN2 | |
| SCHEMBL18762641 | 0.89 | MAPT (0.46) | NPC1RAB9AMAPTTP53SMN1; SMN2 | |
| SCHEMBL18762708 | 0.86 | NAMPT (0.49) | NPC1RAB9AMAPTPOLBALDH1A1 | |
| SCHEMBL18778996 | 0.84 | GSK3B (0.42) | — | |
| SCHEMBL18778986 | 0.82 | MEN1 (0.38) | NPC1RAB9AEPHX1MAPTTP53 | |
| SCHEMBL18778938 | 0.79 | MOGAT2 (0.48) | NPC1RAB9AEPHX1MAPTTP53 | |
| SCHEMBL18778942 | 0.77 | NPC1 (0.41) | NPC1RAB9AEPHX1MAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170114054-A1 | SUBSTITUTED PYRIDINONES AS MGAT2 INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2017-04-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170114054-A1 | SUBSTITUTED PYRIDINONES AS MGAT2 INHIBITORS | PLAAT2, ACAT2, MGAT2 | SPR 1061/4885NPC1 357/4885RAB9A 3511/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.