Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.47 |
| ▸ | KRAS | P01116 | 3/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.43 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.43 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.43 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.41 |
| ▸ | HTR6 | P50406 | 2/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
| ▸ | XIAP | P98170 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1888567 | 1.00 | PTGDR2 (0.47) | PTGDR2KRASHDAC1HDAC6PLA2G2A | |
| SCHEMBL1877905 | 1.00 | PTGDR2 (0.47) | PTGDR2KRASHDAC1HDAC6PLA2G2A | |
| SCHEMBL1877855 | 0.90 | PTGDR2 (0.48) | PTGDR2KRASHDAC1HDAC6MTNR1A | |
| SCHEMBL12637031 | 0.90 | PTGDR2 (0.48) | PTGDR2KRASHDAC1HDAC6MTNR1A | |
| SCHEMBL1875342 | 0.87 | PLA2G2A (0.51) | PTGDR2HDAC1HDAC6PLA2G2AAKR1B10 | |
| SCHEMBL14625187 | 0.83 | PTGDR2 (0.43) | PTGDR2PLA2G2AMTNR1AMTNR1BHTR6 | |
| SCHEMBL3158280 | 0.82 | HDAC1 (0.42) | PTGDR2HDAC1HDAC6AKR1B10AKR1A1 | |
| SCHEMBL1886999 | 0.81 | HDAC1 (0.47) | PTGDR2HDAC1HDAC6MTNR1AMTNR1B | |
| SCHEMBL12637171 | 0.81 | PTGDR2 (0.49) | PTGDR2HDAC1HDAC6MTNR1AMTNR1B | |
| SCHEMBL1871468 | 0.80 | PTGDR2 (0.49) | PTGDR2HDAC1HDAC6MTNR1AMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7935722-B2 | Tetrahydrocarbazole derivatives useful as androgen receptor modulators | ELI LILLY AND COMPANY (US) | 2011-05-03 | — | — | US | disclosed |
| EP-1902026-B1 | TETRAHYDROCARBAZOLE DERIVATIVES USEFUL AS ANDROGEN RECEPTOR MODULATORS (SARM) | LILLY CO ELI (US) | 2010-02-17 | — | — | EP | disclosed |
| US-20100022550-A1 | TETRAHYDROCARBAZOLE DERIVATIVES USEFUL AS ANDROGEN RECEPTOR MODULATORS | CELLECTIS (FR) | 2010-01-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100022550-A1 | TETRAHYDROCARBAZOLE DERIVATIVES USEFUL AS ANDROGEN RECEPTOR MODULATORS | AR, SHBG, CYP17A1 | PTGDR2 437/4885KRAS 4350/4885HDAC1 634/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.