Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 2/20 | 0.46 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.45 |
| ▸ | PBK | Q96KB5 | 1/20 | 0.44 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.43 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.41 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.41 |
| ▸ | PIM1 | P11309 | 2/20 | 0.40 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.40 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.40 |
| ▸ | CDC42BPB | Q9Y5S2 | 3/20 | 0.40 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.40 |
| ▸ | AKT1 | P31749 | 1/20 | 0.40 |
| ▸ | CDC42BPA | Q5VT25 | 1/20 | 0.40 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.40 |
| ▸ | PRKCB | P05771 | 1/20 | 0.40 |
| ▸ | PRKCA | P17252 | 1/20 | 0.40 |
| ▸ | PRKCH | P24723 | 1/20 | 0.40 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21698694 | 0.90 | CCNC (0.45) | HRH4CHRNB2CHRNA4CCNCCDK8 | |
| SCHEMBL23132877 | 0.86 | DOT1L (0.44) | MAP4K4DOT1LPBKHRH4PIM1 | |
| SCHEMBL4826795 | 0.83 | CHRNB2 (0.55) | DOT1LPBKCHRNB2CHRNA4PIM1 | |
| SCHEMBL22774088 | 0.83 | DOT1L (0.44) | MAP4K4DOT1LPBKHRH4CHRNB2 | |
| SCHEMBL4827711 | 0.83 | CHRNB2 (0.56) | MAP4K4DOT1LPBKHRH4CHRNB2 | |
| SCHEMBL25372604 | 0.83 | DOT1L (0.44) | MAP4K4DOT1LPBKHRH4CHRNB2 | |
| SCHEMBL24747237 | 0.83 | CHRNB2 (0.40) | CHRNB2CHRNA4ALOX5APFEN1 | |
| SCHEMBL25065178 | 0.83 | MAP4K4 (0.47) | MAP4K4CHRNB2CHRNA4CDK8 | |
| SCHEMBL25373756 | 0.83 | CHRNB2 (0.56) | MAP4K4DOT1LPBKHRH4CHRNB2 | |
| SCHEMBL23504190 | 0.83 | DOT1L (0.44) | MAP4K4DOT1LPBKHRH4CHRNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9630970-B2 | TYK2 inhibitors and uses thereof | NIMBUS LAKSHMI, INC. (US) | 2017-04-25 | — | — | US | disclosed |