Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 3/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.37 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.36 |
| ▸ | FEN1 | P39748 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | GCK | P35557 | 1/20 | 0.35 |
| ▸ | GCKR | Q14397 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.35 |
| ▸ | MTOR | P42345 | 2/20 | 0.35 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30316329 | 1.00 | CHRNB2 (0.40) | CHRNB2CHRNA4LRRK2DEGS1CHRM3 | |
| SCHEMBL18291319 | 0.83 | MAPT (0.48) | CHRNB2CHRNA4MAPTGCKGCKR | |
| SCHEMBL18779659 | 0.83 | MAP4K4 (0.46) | CHRNB2CHRNA4ALOX5APFEN1 | |
| SCHEMBL30316041 | 0.81 | SMPD3 (0.47) | CHRNB2CHRNA4LRRK2ALOX5APFEN1 | |
| SCHEMBL17799085 | 0.81 | SMPD3 (0.47) | CHRNB2CHRNA4LRRK2ALOX5APFEN1 | |
| SCHEMBL30316026 | 0.81 | SMPD3 (0.47) | CHRNB2CHRNA4LRRK2ALOX5APFEN1 | |
| SCHEMBL17796348 | 0.81 | SMPD3 (0.47) | CHRNB2CHRNA4LRRK2ALOX5APFEN1 | |
| SCHEMBL25065178 | 0.81 | MAP4K4 (0.47) | CHRNB2CHRNA4LRRK2MAPT | |
| SCHEMBL24746250 | 0.81 | SLC6A9 (0.41) | CHRNB2CHRNA4LRRK2DEGS1CHRM3 | |
| SCHEMBL17054803 | 0.81 | SMPD3 (0.47) | CHRNB2CHRNA4LRRK2ALOX5APFEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230096641-A1 | HPK1 ANTAGONISTS AND USES THEREOF | NIMBUS DISCOVERY, INC. | 2023-03-30 | — | — | US | disclosed |
| WO-2022174253-A1 | HPK1 ANTAGONISTS AND USES THEREOF | Nimbus Saturn, Inc. (US) | 2022-08-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230096641-A1 | HPK1 ANTAGONISTS AND USES THEREOF | PDXK, HIPK1, PCK1 | CHRNB2 3697/4885CHRNA4 4574/4885LRRK2 972/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.