SCHEMBL18779752

SCHEMBL18779752

C/C=C/Nc1ccccc1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 0.52
NPC1 O15118 5/20 0.48
RAB9A P51151 5/20 0.48
SMN1; SMN2 Q16637 2/20 0.48
NPSR1 Q6W5P4 2/20 0.48
NFKB1 P19838 1/20 0.48
NFKB2 Q00653 1/20 0.48
RELA Q04206 1/20 0.48
TSHR P16473 2/20 0.46
IDO1 P14902 2/20 0.46
KMT2A Q03164 2/20 0.45
TDP1 Q9NUW8 5/20 0.43
HSD17B10 Q99714 2/20 0.43
KDM4E B2RXH2 2/20 0.43
ADRB2 P07550 1/20 0.43
CTSD P07339 1/20 0.43
PTGS2 P35354 2/20 0.41
ALOX15 P16050 2/20 0.41
MAPK1 P28482 2/20 0.41
L3MBTL1 Q9Y468 2/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5569513 1.00 ALDH1A1 (0.52) ALDH1A1NPC1RAB9ASMN1; SMN2NPSR1
SCHEMBL6259235 1.00 ALDH1A1 (0.52) ALDH1A1NPC1RAB9ASMN1; SMN2NPSR1
Benzene SCHEMBL10426584 1.00 ALDH1A1 (0.52) ALDH1A1NPC1RAB9ASMN1; SMN2NPSR1
Hydrochloric Acid SCHEMBL28544957 0.97 ALDH1A1 (0.50) ALDH1A1NPC1RAB9ASMN1; SMN2NPSR1
SCHEMBL998879 0.85 KMT2A (0.53) ALDH1A1NPC1RAB9ASMN1; SMN2NPSR1
SCHEMBL20881023 0.85 KMT2A (0.53) ALDH1A1NPC1RAB9ASMN1; SMN2NPSR1
SCHEMBL19530361 0.85 KMT2A (0.53) ALDH1A1NPC1RAB9ASMN1; SMN2NPSR1
SCHEMBL223591 0.85 ALDH1A1 (0.60) ALDH1A1NPC1RAB9ASMN1; SMN2NPSR1
SCHEMBL223592 0.85 ALDH1A1 (0.60) ALDH1A1NPC1RAB9ASMN1; SMN2NPSR1
Hydrochloric Acid SCHEMBL997093 0.84 KMT2A (0.52) ALDH1A1NPC1RAB9ASMN1; SMN2NPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023004356-A2 AZAINDOLE CYANINE DYES, USES, AND METHODS OF PREPARATION Life Technologies Corporation (US) 2023-01-26 WO disclosed
WO-2022129336-A1 PH RESPONSIVE CYANINE DYES AND CONJUGATES THEREOF BRACCO IMAGING SPA (IT) 2022-06-23 WO disclosed
EP-3476830-A1 POLYMETHINE COMPOUNDS AND THEIR USE AS FLUORESCENT LABELS Illumina Cambridge Limited (GB) 2019-05-01 EP disclosed
EP-3321246-A2 DOUBLE SPIRO COMPOUND AND ORGANIC LIGHT-EMITTING ELEMENT COMPRISING SAME LG Chem, Ltd. (KR) 2018-05-16 EP disclosed
US-9631096-B2 Dye compositions, methods of preparation, conjugates thereof, and methods of use CORNELL UNIVERSITY (US) 2017-04-25 US disclosed