Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 4/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | LCK | P06239 | 4/20 | 0.39 |
| ▸ | SRC | P12931 | 4/20 | 0.39 |
| ▸ | TEK | Q02763 | 4/20 | 0.39 |
| ▸ | MTOR | P42345 | 2/20 | 0.39 |
| ▸ | AKT1 | P31749 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.37 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | KDR | P35968 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | RGS12 | O14924 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18780378 | 0.99 | BTK (0.52) | BTKLMNAHSD17B10USP2TSHR | |
| SCHEMBL18780297 | 0.90 | BTK (0.50) | BTKLCKSRCTEKCSNK1D | |
| SCHEMBL18780299 | 0.89 | BTK (0.52) | BTKLMNAHSD17B10LCKSRC | |
| SCHEMBL18780268 | 0.86 | BTK (0.51) | BTKLCKSRCTEKKDR | |
| SCHEMBL18780296 | 0.86 | MEN1 (0.49) | BTKLMNAHTTKDM4EMEN1 | |
| SCHEMBL18780263 | 0.82 | BTK (0.53) | BTKLCKSRCTEKNPC1 | |
| SCHEMBL18780337 | 0.82 | BTK (0.48) | BTKNPC1 | |
| SCHEMBL18780324 | 0.80 | BTK (0.64) | BTKSCN9A | |
| SCHEMBL16168585 | 0.79 | BTK (0.53) | BTKLCKSRCTEKNPC1 | |
| SCHEMBL18780380 | 0.78 | BTK (0.54) | BTKLMNAHPGDMEN1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2789614-B1 | Azaindazoles as Btk kinase modulators and use thereof | BRISTOL MYERS SQUIBB CO (US) | 2017-04-26 | — | — | EP | disclosed |