Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | PARP14 | Q460N5 | 4/20 | 0.48 |
| ▸ | PARP10 | Q53GL7 | 4/20 | 0.48 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.47 |
| ▸ | BTK | Q06187 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | MGLL | Q99685 | 2/20 | 0.43 |
| ▸ | GBA1 | P04062 | 2/20 | 0.42 |
| ▸ | CKS1B | P61024 | 1/20 | 0.42 |
| ▸ | SKP1 | P63208 | 1/20 | 0.42 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | CRHBP | P24387 | 1/20 | 0.42 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.42 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.42 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.42 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18780334 | 0.86 | BTK (0.52) | MEN1KMT2ABTKHTTMAPT | |
| SCHEMBL18780297 | 0.85 | BTK (0.50) | BTK | |
| SCHEMBL18780378 | 0.85 | BTK (0.52) | MEN1KMT2ABTKHTTMAPT | |
| SCHEMBL18780337 | 0.83 | BTK (0.48) | BTKCKS1BSKP1SKP2PRSS1 | |
| SCHEMBL18780299 | 0.82 | BTK (0.52) | MEN1KMT2ABTKCKS1BSKP1 | |
| SCHEMBL18780338 | 0.80 | RAB9A (0.50) | MEN1KMT2APARP14PARP10BTK | |
| SCHEMBL18780268 | 0.80 | BTK (0.51) | BTK | |
| SCHEMBL6116269 | 0.80 | ABL1 (0.51) | MEN1KMT2ASLC6A7BTK | |
| SCHEMBL18780324 | 0.77 | BTK (0.64) | BTKCKS1BSKP1SKP2 | |
| SCHEMBL18780263 | 0.76 | BTK (0.53) | BTKPRSS1PRSS2PRSS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2789614-B1 | Azaindazoles as Btk kinase modulators and use thereof | BRISTOL MYERS SQUIBB CO (US) | 2017-04-26 | — | — | EP | disclosed |