Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 4/20 | 0.48 |
| ▸ | TMPRSS15 | P98073 | 2/20 | 0.47 |
| ▸ | CKS1B | P61024 | 1/20 | 0.46 |
| ▸ | SKP1 | P63208 | 1/20 | 0.46 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.46 |
| ▸ | ST14 | Q9Y5Y6 | 7/20 | 0.45 |
| ▸ | F2 | P00734 | 5/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | F10 | P00742 | 2/20 | 0.44 |
| ▸ | PRSS1 | P07477 | 4/20 | 0.44 |
| ▸ | PRSS2 | P07478 | 4/20 | 0.44 |
| ▸ | PRSS3 | P35030 | 4/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.43 |
| ▸ | PLG | P00747 | 2/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18780324 | 0.87 | BTK (0.64) | BTKCKS1BSKP1SKP2AURKA | |
| SCHEMBL18780299 | 0.84 | BTK (0.52) | BTKCKS1BSKP1SKP2NPC1 | |
| SCHEMBL18780383 | 0.83 | NPC1 (0.54) | BTKST14F2NPC1F10 | |
| SCHEMBL18780296 | 0.83 | MEN1 (0.49) | BTKCKS1BSKP1SKP2PRSS1 | |
| SCHEMBL18780335 | 0.83 | BTK (0.70) | BTKCKS1BSKP1SKP2AURKA | |
| SCHEMBL18780334 | 0.82 | BTK (0.52) | BTKNPC1 | |
| SCHEMBL6115795 | 0.82 | BTK (0.54) | BTKCKS1BSKP1SKP2NPC1 | |
| SCHEMBL18780268 | 0.82 | BTK (0.51) | BTK | |
| SCHEMBL18780378 | 0.81 | BTK (0.52) | BTKNPC1F10 | |
| SCHEMBL18780297 | 0.80 | BTK (0.50) | BTKPDPK1AURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2789614-B1 | Azaindazoles as Btk kinase modulators and use thereof | BRISTOL MYERS SQUIBB CO (US) | 2017-04-26 | — | — | EP | disclosed |