Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 5/20 | 0.70 |
| ▸ | AURKA | O14965 | 3/20 | 0.47 |
| ▸ | PDPK1 | O15530 | 3/20 | 0.47 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.47 |
| ▸ | CKS1B | P61024 | 1/20 | 0.46 |
| ▸ | SKP1 | P63208 | 1/20 | 0.46 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.44 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.43 |
| ▸ | SUV39H2 | Q9H5I1 | 4/20 | 0.42 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.42 |
| ▸ | SYK | P43405 | 1/20 | 0.41 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.41 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.41 |
| ▸ | ITGAL | P20701 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18780324 | 0.96 | BTK (0.64) | BTKAURKAPDPK1AURKBCKS1B | |
| SCHEMBL12874700 | 0.87 | BTK (0.60) | BTKAURKAPDPK1AURKBCKS1B | |
| SCHEMBL6116715 | 0.84 | BTK (0.80) | BTKAURKAPDPK1AURKBCKS1B | |
| SCHEMBL18780337 | 0.83 | BTK (0.48) | BTKAURKAPDPK1AURKBCKS1B | |
| SCHEMBL18780381 | 0.81 | BTK (0.72) | BTK | |
| SCHEMBL18780268 | 0.80 | BTK (0.51) | BTKSCN9A | |
| SCHEMBL8557909 | 0.79 | BTK (0.72) | BTKAURKAPDPK1AURKBCKS1B | |
| SCHEMBL18780299 | 0.79 | BTK (0.52) | BTKCKS1BSKP1SKP2SCN9A | |
| SCHEMBL18068379 | 0.77 | BTK (0.59) | BTKCKS1BSKP1SKP2SCN9A | |
| SCHEMBL18780334 | 0.77 | BTK (0.52) | BTKSCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2789614-B1 | Azaindazoles as Btk kinase modulators and use thereof | BRISTOL MYERS SQUIBB CO (US) | 2017-04-26 | — | — | EP | disclosed |