Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 5/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | RPS6KA2 | Q15349 | 1/20 | 0.37 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.37 |
| ▸ | ATR | Q13535 | 2/20 | 0.37 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.36 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.36 |
| ▸ | GCK | P35557 | 1/20 | 0.36 |
| ▸ | KIT | P10721 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
| ▸ | FYN | P06241 | 1/20 | 0.35 |
| ▸ | FABP1 | P07148 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6116264 | 0.79 | BTK (0.51) | BTKKDRNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL16168570 | 0.72 | RPS6KA2 (0.36) | KDRNPC1RAB9ASMN1; SMN2RPS6KA2 | |
| SCHEMBL13801599 | 0.66 | NPC1 (0.50) | KDRNPC1RAB9ARPS6KA2SIRT2 | |
| SCHEMBL5557458 | 0.66 | MEN1 (0.57) | KDRNPC1RAB9ASMN1; SMN2RPS6KA2 | |
| SCHEMBL7433791 | 0.66 | NPC1 (0.58) | NPC1RAB9ASMN1; SMN2RPS6KA2FLT3 | |
| SCHEMBL6115598 | 0.65 | BTK (0.58) | BTKKDRCHEK2KITFLT3 | |
| SCHEMBL6115982 | 0.62 | BTK (0.56) | BTKKITFLT3FYN | |
| SCHEMBL18780329 | 0.62 | PLAU (0.53) | BTKNPC1RAB9ASMN1; SMN2ATR | |
| SCHEMBL6115656 | 0.62 | BTK (0.69) | BTK | |
| SCHEMBL6115612 | 0.61 | BTK (0.57) | BTKATR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2789614-B1 | Azaindazoles as Btk kinase modulators and use thereof | BRISTOL MYERS SQUIBB CO (US) | 2017-04-26 | — | — | EP | disclosed |