Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.57 |
| ▸ | NPC1 | O15118 | 3/20 | 0.57 |
| ▸ | RAB9A | P51151 | 3/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | KCNK3 | O14649 | 5/20 | 0.54 |
| ▸ | KCNK9 | Q9NPC2 | 4/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | GRM5 | P41594 | 1/20 | 0.51 |
| ▸ | FOXO1 | Q12778 | 1/20 | 0.51 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | EGFR | P00533 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7433791 | 0.85 | NPC1 (0.58) | NPC1RAB9AKCNK3KCNK9SMN1; SMN2 | |
| SCHEMBL13801599 | 0.81 | NPC1 (0.50) | MEN1KMT2ANPC1RAB9APOLB | |
| SCHEMBL4352826 | 0.77 | TOP1 (0.55) | NPC1RAB9ASMN1; SMN2KDM4EEGFR | |
| SCHEMBL9269321 | 0.77 | GRIK1 (0.56) | NPC1RAB9ASMN1; SMN2KDM4EEGFR | |
| SCHEMBL3569428 | 0.76 | NPC1 (0.71) | NPC1RAB9ASMN1; SMN2KDM4EEGFR | |
| SCHEMBL8558926 | 0.76 | RAB9A (0.81) | MEN1KMT2ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL4413986 | 0.76 | MTNR1A (0.53) | KMT2ANPC1RAB9APOLBSMN1; SMN2 | |
| SCHEMBL31487774 | 0.76 | MTNR1A (0.53) | KMT2ANPC1RAB9APOLBSMN1; SMN2 | |
| SCHEMBL10227495 | 0.75 | PDGFRB (0.68) | MEN1KMT2ANPC1RAB9ARXFP1 | |
| SCHEMBL22488995 | 0.75 | FOXO1 (0.68) | MEN1KMT2ANPC1RAB9APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1756112-A1 | PYRROLOBENZIMIDAZOLONES AND THEIR USE AS ANTIPROLIFERATIVE AGENTS | Boehringer Ingelheim International GmbH (DE) | 2007-02-28 | — | — | EP | disclosed |
| WO-2005111040-A1 | PYRROLOBENZIMIDAZOLONES AND THEIR USE AS ANTIPROLIFERATIVE AGENTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2005-11-24 | — | — | WO | disclosed |