Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 2/20 | 0.53 |
| ▸ | F2 | P00734 | 1/20 | 0.47 |
| ▸ | PLG | P00747 | 1/20 | 0.47 |
| ▸ | PLAT | P00750 | 1/20 | 0.47 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.47 |
| ▸ | KLK1 | P06870 | 1/20 | 0.47 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.47 |
| ▸ | BTK | Q06187 | 2/20 | 0.47 |
| ▸ | FABP1 | P07148 | 2/20 | 0.47 |
| ▸ | PGR | P06401 | 2/20 | 0.46 |
| ▸ | ATR | Q13535 | 4/20 | 0.46 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.46 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.46 |
| ▸ | PRKDC | P78527 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16168586 | 0.90 | BTK (0.48) | PLAUF2BTKFABP1MEN1 | |
| SCHEMBL18780323 | 0.88 | BTK (0.52) | F2BTK | |
| SCHEMBL18780265 | 0.86 | BTK (0.52) | PLAUF2BTKATR | |
| SCHEMBL18780383 | 0.86 | NPC1 (0.54) | F2PLGPRSS1BTKATR | |
| SCHEMBL18780327 | 0.82 | BTK (0.54) | F2BTKMEN1KMT2ANPC1 | |
| SCHEMBL18780267 | 0.81 | BTK (0.53) | F2BTKMEN1KMT2ANPC1 | |
| SCHEMBL18780264 | 0.81 | BTK (0.55) | PLGPLATPRSS1BTKATR | |
| SCHEMBL18780343 | 0.80 | BTK (0.50) | BTKNPC1RAB9A | |
| SCHEMBL6115598 | 0.80 | BTK (0.58) | BTKFABP1PGR | |
| SCHEMBL18780338 | 0.79 | RAB9A (0.50) | BTKATRMEN1KMT2ARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2789614-B1 | Azaindazoles as Btk kinase modulators and use thereof | BRISTOL MYERS SQUIBB CO (US) | 2017-04-26 | — | — | EP | disclosed |