Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 15/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 14/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 10/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16408261 | 1.00 | SLC6A4 (0.41) | SLC6A4SLC6A2KCNH2SLC6A3CYP2D6 | |
| SCHEMBL16408198 | 1.00 | SLC6A4 (0.41) | SLC6A4SLC6A2KCNH2SLC6A3CYP2D6 | |
| SCHEMBL16408196 | 0.92 | KDM4E (0.40) | SLC6A4SLC6A2KCNH2KDM4ELMNA | |
| SCHEMBL30419208 | 0.83 | SLC6A4 (0.46) | SLC6A4SLC6A2KCNH2SLC6A3CYP2D6 | |
| SCHEMBL30419218 | 0.83 | SLC6A4 (0.46) | SLC6A4SLC6A2KCNH2SLC6A3CYP2D6 | |
| SCHEMBL30419169 | 0.83 | SLC6A4 (0.46) | SLC6A4SLC6A2KCNH2SLC6A3CYP2D6 | |
| SCHEMBL11283749 | 0.78 | KDM4E (0.51) | KDM4ELMNAALDH1A1MEN1RAB9A | |
| SCHEMBL24327704 | 0.78 | SLC6A4 (0.46) | SLC6A4SLC6A2KCNH2SLC6A3CYP2D6 | |
| SCHEMBL16408232 | 0.78 | SLC6A4 (0.46) | SLC6A4SLC6A2KCNH2SLC6A3CYP2D6 | |
| SCHEMBL13673559 | 0.78 | SLC6A4 (0.46) | SLC6A4SLC6A2KCNH2SLC6A3CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3022194-B1 | INHIBITORS OF LEUKOTRIENE PRODUCTION | BOEHRINGER INGELHEIM INT (DE) | 2017-05-17 | — | — | EP | disclosed |
| EP-3022193-B1 | INHIBITORS OF LEUKOTRIENE PRODUCTION | BOEHRINGER INGELHEIM INT (DE) | 2017-04-26 | — | — | EP | disclosed |