Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 9/20 | 0.39 |
| ▸ | FABP4 | P15090 | 1/20 | 0.33 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.33 |
| ▸ | NAT1 | P18440 | 1/20 | 0.33 |
| ▸ | P4HB | P07237 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 1/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | GFER | P55789 | 1/20 | 0.30 |
| ▸ | ITGAV | P06756 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18784222 | 0.87 | METAP2 (0.41) | METAP2FABP4FABP5CYP3A4CYP2C9 | |
| SCHEMBL1648655 | 0.85 | METAP2 (0.48) | METAP2FABP4FABP5 | |
| SCHEMBL1648156 | 0.84 | METAP2 (0.43) | METAP2FABP4FABP5CYP3A4CYP2C9 | |
| SCHEMBL1649183 | 0.81 | METAP2 (0.52) | METAP2FABP4FABP5 | |
| SCHEMBL1648326 | 0.79 | METAP2 (0.47) | METAP2FABP4FABP5 | |
| SCHEMBL18784232 | 0.75 | METAP2 (0.47) | METAP2FABP4FABP5HTTCYP3A4 | |
| SCHEMBL18784217 | 0.74 | GBA1 (0.34) | METAP2NAT1ALDH1A1 | |
| SCHEMBL1648930 | 0.72 | METAP2 (0.47) | METAP2FABP4FABP5 | |
| SCHEMBL18784220 | 0.72 | METAP2 (0.47) | METAP2FABP4FABP5CA12CA1 | |
| SCHEMBL1647920 | 0.71 | METAP2 (0.43) | METAP2FABP4FABP5BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2486004-B1 | SULPHONE COMPOUNDS FOR USE IN THE TREATMENT OF OBESITY | ZAFGEN INC (US) | 2017-05-03 | — | — | EP | disclosed |