Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 13/20 | 0.47 |
| ▸ | FABP4 | P15090 | 1/20 | 0.35 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.35 |
| ▸ | TOP2A | P11388 | 1/20 | 0.34 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.34 |
| ▸ | TERT | O14746 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.31 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.31 |
| ▸ | PIM1 | P11309 | 1/20 | 0.31 |
| ▸ | IDO1 | P14902 | 1/20 | 0.31 |
| ▸ | LTK | P29376 | 1/20 | 0.31 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.31 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1648655 | 0.89 | METAP2 (0.48) | METAP2FABP4FABP5 | |
| SCHEMBL18801044 | 0.85 | METAP2 (0.44) | METAP2FABP4FABP5TOP2ATOP2B | |
| SCHEMBL1649183 | 0.85 | METAP2 (0.52) | METAP2FABP4FABP5 | |
| SCHEMBL1648156 | 0.83 | METAP2 (0.43) | METAP2FABP4FABP5TOP2ATOP2B | |
| SCHEMBL1648930 | 0.80 | METAP2 (0.47) | METAP2FABP4FABP5 | |
| SCHEMBL18784222 | 0.80 | METAP2 (0.41) | METAP2FABP4FABP5CYP3A4CYP2C9 | |
| SCHEMBL18801365 | 0.78 | METAP2 (0.39) | METAP2TOP2ATOP2BTERTCYP3A4 | |
| SCHEMBL1648326 | 0.78 | METAP2 (0.47) | METAP2FABP4FABP5TERTMAPT | |
| SCHEMBL1648737 | 0.78 | METAP2 (0.46) | METAP2FABP4FABP5ALDH1A1KDM4E | |
| SCHEMBL1647756 | 0.76 | METAP2 (0.53) | METAP2FABP4FABP5ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2486004-B1 | SULPHONE COMPOUNDS FOR USE IN THE TREATMENT OF OBESITY | ZAFGEN INC (US) | 2017-05-03 | — | — | EP | claimed |