Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 8/20 | 0.44 |
| ▸ | TOP2A | P11388 | 1/20 | 0.33 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.33 |
| ▸ | FABP4 | P15090 | 1/20 | 0.32 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.31 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.31 |
| ▸ | PIM1 | P11309 | 1/20 | 0.31 |
| ▸ | IDO1 | P14902 | 1/20 | 0.31 |
| ▸ | LTK | P29376 | 1/20 | 0.31 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 4/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.31 |
| ▸ | HTT | P42858 | 3/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18801365 | 0.93 | METAP2 (0.39) | METAP2TOP2ATOP2BNPSR1CLK4 | |
| SCHEMBL18801276 | 0.86 | METAP2 (0.42) | METAP2FABP4FABP5HTTLMNA | |
| SCHEMBL18784232 | 0.85 | METAP2 (0.47) | METAP2TOP2ATOP2BFABP4FABP5 | |
| SCHEMBL18801427 | 0.85 | METAP2 (0.42) | METAP2MAPTALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL1648655 | 0.83 | METAP2 (0.48) | METAP2FABP4FABP5 | |
| SCHEMBL18801101 | 0.81 | METAP2 (0.39) | METAP2FABP4FABP5NPSR1GAA | |
| SCHEMBL18801150 | 0.80 | METAP2 (0.48) | METAP2FABP4FABP5CYP3A4CYP2C19 | |
| SCHEMBL18801061 | 0.80 | METAP2 (0.43) | METAP2FABP4FABP5MAPTALDH1A1 | |
| SCHEMBL18801358 | 0.79 | METAP2 (0.38) | METAP2CLK4MAPTALDH1A1CYP1A2 | |
| SCHEMBL1649341 | 0.79 | METAP2 (0.47) | METAP2FABP4FABP5ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2486004-B1 | SULPHONE COMPOUNDS FOR USE IN THE TREATMENT OF OBESITY | ZAFGEN INC (US) | 2017-05-03 | — | — | EP | disclosed |