Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP46A1 | Q9Y6A2 | 2/20 | 0.47 |
| ▸ | USP2 | O75604 | 2/20 | 0.47 |
| ▸ | OSBP | P22059 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.47 |
| ▸ | RORC | P51449 | 1/20 | 0.47 |
| ▸ | OSBP2 | Q969R2 | 1/20 | 0.47 |
| ▸ | POLA1 | P09884 | 1/20 | 0.46 |
| ▸ | ST6GAL1 | P15907 | 2/20 | 0.45 |
| ▸ | ST3GAL1 | Q11201 | 2/20 | 0.45 |
| ▸ | ST3GAL3 | Q11203 | 1/20 | 0.44 |
| ▸ | NR1H3 | Q13133 | 6/20 | 0.43 |
| ▸ | APP | P05067 | 1/20 | 0.43 |
| ▸ | NPC1L1 | Q9UHC9 | 2/20 | 0.42 |
| ▸ | DHCR24 | Q15392 | 1/20 | 0.42 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1878892 | 1.00 | CYP46A1 (0.47) | CYP46A1USP2OSBPLMNAABCB1 | |
| SCHEMBL13311391 | 1.00 | CYP46A1 (0.47) | CYP46A1USP2OSBPLMNAABCB1 | |
| SCHEMBL12639020 | 1.00 | CYP46A1 (0.47) | CYP46A1USP2OSBPLMNAABCB1 | |
| SCHEMBL13345778 | 0.95 | ST6GAL1 (0.44) | CYP46A1USP2OSBPLMNAABCB1 | |
| SCHEMBL12639010 | 0.94 | OSBP (0.46) | CYP46A1USP2OSBPLMNAABCB1 | |
| SCHEMBL12639002 | 0.94 | OSBP (0.46) | CYP46A1USP2OSBPLMNAABCB1 | |
| SCHEMBL1881130 | 0.94 | OSBP (0.46) | CYP46A1USP2OSBPLMNAABCB1 | |
| SCHEMBL13311388 | 0.94 | OSBP (0.46) | CYP46A1USP2OSBPLMNAABCB1 | |
| SCHEMBL1879721 | 0.94 | OSBP (0.46) | CYP46A1USP2OSBPLMNAABCB1 | |
| SCHEMBL1881129 | 0.94 | OSBP (0.46) | CYP46A1USP2OSBPLMNAABCB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8198230-B2 | Synthetic mimics of mammalian cell surface receptors: method and compositions | THE PENN STATE RESEARCH FOUNDATION (US) | 2012-06-12 | — | — | US | disclosed |
| US-20110236344-A1 | Synthetic mimics of mammalian cell surface receptors: method and compositions | THE PENN STATE RESEARCH FOUNDATION (US) | 2011-09-29 | — | — | US | disclosed |
| US-7956029-B2 | Synthetic mimics of mammalian cell surface receptors: method and compositions | THE PENN STATE RESEARCH FOUNDATION (US) | 2011-06-07 | — | — | US | disclosed |
| US-7947647-B2 | Synthetic mimics of mammalian cell surface receptors: method and compositions | THE PENN STATE RESEARCH FOUNDATION (US) | 2011-05-24 | — | — | US | disclosed |
| WO-2010071772-A2 | SYNTHESIS OF 3B-AMINO-5-CHOLESTENE AND RELATED 3B-HALIDES INVOLVING I-STEROID AND RETRO-I-STEROID REARRANGEMENTS | THE PENN STATE RESEARCH FOUNDATION (US) | 2010-06-24 | — | — | WO | disclosed |
| US-20100160657-A1 | SYNTHETIC MIMICS OF MAMMALIAN CELL SURFACE RECEPTORS: METHOD AND COMPOSITIONS | THE PENN STATE RESEARCH FOUNDATION (US) | 2010-06-24 | — | — | US | disclosed |
| US-20100029906-A1 | Synthetic mimics of mammalian cell surface receptors: method and compositions | THE PENN STATE RESEARCH FOUNDATION (US) | 2010-02-04 | — | — | US | disclosed |
| US-20090197848-A1 | Synthetic mimics of mammalian cell surface receptors: method and compositions | THE PENN STATE RESEARCH FOUNDATION (US) | 2009-08-06 | — | — | US | disclosed |
| US-7514400-B2 | Synthetic mimics of mammalian cell surface receptors: method and compositions | THE PENN STATE RESEARCH FOUNDATION (US) | 2009-04-07 | — | — | US | disclosed |
| US-20060229235-A1 | Synthetic mimics of mammalian cell surface receptors: method and compositions | THE PENN STATE RESEARCH FOUNDATION (US) | 2006-10-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100160657-A1 | SYNTHETIC MIMICS OF MAMMALIAN CELL SURFACE RECEPTORS: METHOD AND COMPOSITIONS | NR1H4, LDLR, NR1H3 | CYP46A1 13/4885USP2 3383/4885OSBP 350/4885 |
| US-20090197848-A1 | Synthetic mimics of mammalian cell surface receptors: method and compositions | MSR1, M6PR, ASGR1 | CYP46A1 2149/4885USP2 3017/4885OSBP 1540/4885 |
| US-20060229235-A1 | Synthetic mimics of mammalian cell surface receptors: method and compositions | MSR1, M6PR, ASGR1 | CYP46A1 2149/4885USP2 3017/4885OSBP 1540/4885 |
| US-20100029906-A1 | Synthetic mimics of mammalian cell surface receptors: method and compositions | MSR1, M6PR, ASGR1 | CYP46A1 2149/4885USP2 3017/4885OSBP 1540/4885 |
| US-20110236344-A1 | Synthetic mimics of mammalian cell surface receptors: method and compositions | MSR1, M6PR, ASGR1 | CYP46A1 2149/4885USP2 3017/4885OSBP 1540/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.