Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 4/20 | 0.63 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.60 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.60 |
| ▸ | ACE | P12821 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 4/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.57 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.57 |
| ▸ | ATM | Q13315 | 1/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.57 |
| ▸ | RECQL | P46063 | 1/20 | 0.57 |
| ▸ | CTSL | P07711 | 3/20 | 0.56 |
| ▸ | CTSB | P07858 | 1/20 | 0.56 |
| ▸ | CTSS | P25774 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.56 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.55 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18775039 | 1.00 | CTSK (0.63) | CTSKS1PR4S1PR1ACEMAPT | |
| SCHEMBL29272932 | 0.92 | S1PR4 (0.56) | CTSKS1PR4S1PR1MAPTALDH1A1 | |
| SCHEMBL29272930 | 0.92 | S1PR4 (0.56) | CTSKS1PR4S1PR1MAPTALDH1A1 | |
| SCHEMBL29272857 | 0.90 | S1PR4 (0.54) | CTSKS1PR4S1PR1MAPTALDH1A1 | |
| SCHEMBL29272856 | 0.90 | S1PR4 (0.54) | CTSKS1PR4S1PR1MAPTALDH1A1 | |
| SCHEMBL11432342 | 0.87 | CTSK (0.61) | CTSKS1PR4S1PR1MAPTALDH1A1 | |
| SCHEMBL16272916 | 0.86 | CTSK (0.76) | CTSKCTSLCTSBCTSS | |
| SCHEMBL18775048 | 0.86 | CTSK (0.60) | CTSKS1PR4S1PR1MAPTALDH1A1 | |
| SCHEMBL25634730 | 0.86 | CTSK (0.60) | CTSKS1PR4S1PR1MAPTALDH1A1 | |
| SCHEMBL839616 | 0.86 | CTSL (0.59) | CTSKCTSLCTSBCTSSTAS1R3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116370448-A | Modulators of SESTRIN-GATOR2 interactions and uses thereof | 纳维托制药有限公司 | 2023-07-04 | — | — | CN | disclosed |
| CN-110809467-B | Modulators of SESTRIN-GATOR2 interactions and uses thereof | 纳维托制药有限公司 | 2023-03-10 | — | — | CN | disclosed |
| EP-4112611-A2 | MODULATORS OF SESTRIN-GATOR2 INTERACTION AND USES THEREOF | Navitor Pharmaceuticals, Inc. (US) | 2023-01-04 | — | — | EP | disclosed |
| EP-3364958-B1 | MODULATORS OF SESTRIN-GATOR2 INTERACTION AND USES THEREOF | NAVITOR PHARM INC (US) | 2023-01-04 | — | — | EP | disclosed |
| CN-110809467-A | Modulators of SESTRIN-GATOR2 interaction and uses thereof | 纳维托制药有限公司 | 2020-02-18 | — | — | CN | disclosed |
| WO-2017070518-A1 | MODULATORS OF SESTRIN-GATOR2 INTERACTION AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2017-04-27 | — | — | WO | disclosed |