Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 13/20 | 0.71 |
| ▸ | ROCK1 | Q13464 | 7/20 | 0.71 |
| ▸ | HAVCR2 | Q8TDQ0 | 2/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.40 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.39 |
| ▸ | SLC2A3 | P11169 | 1/20 | 0.39 |
| ▸ | CLK2 | P49760 | 1/20 | 0.39 |
| ▸ | BLK | P51451 | 1/20 | 0.39 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.39 |
| ▸ | STK3 | Q13188 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.39 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | CDK8 | P49336 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17070953 | 0.83 | ROCK2 (1.00) | ROCK2ROCK1CLK2BLKCSNK2A1 | |
| SCHEMBL17038099 | 0.81 | ROCK2 (0.70) | ROCK2ROCK1HAVCR2NOTUMSLC2A1 | |
| SCHEMBL18792356 | 0.73 | ROCK2 (0.66) | ROCK2ROCK1SLC2A1SLC2A3 | |
| SCHEMBL18792298 | 0.71 | ROCK2 (0.68) | ROCK2ROCK1SLC2A1SLC2A3 | |
| SCHEMBL23380752 | 0.69 | ROCK2 (0.66) | ROCK2ROCK1 | |
| SCHEMBL17038102 | 0.68 | ROCK2 (1.00) | ROCK2ROCK1SLC2A1SLC2A3CLK2 | |
| SCHEMBL20030093 | 0.68 | ROCK1 (0.64) | ROCK2ROCK1SLC2A1SLC2A3CLK2 | |
| SCHEMBL17040533 | 0.67 | ROCK2 (1.00) | ROCK2ROCK1SLC2A1SLC2A3CLK2 | |
| SCHEMBL24943925 | 0.67 | ROCK2 (0.67) | ROCK2ROCK1 | |
| SCHEMBL24862354 | 0.67 | ROCK2 (0.69) | ROCK2ROCK1SLC2A1SLC2A3CLK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11311541-B2 | Treatment of GVHD | KADMON CORPORATION, LLC (US) | 2022-04-26 | — | — | US | disclosed |
| US-20170112832-A1 | TREATMENT OF GVHD | KADMON CORPORATION, LLC | 2017-04-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170112832-A1 | TREATMENT OF GVHD | ROCK2, ROCK1, RHOA | ROCK2 1/4885ROCK1 2/4885HAVCR2 920/4885 |
| US-11311541-B2 | Treatment of GVHD | ROCK2, ROCK1, RHOA | ROCK2 1/4885ROCK1 2/4885HAVCR2 920/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.