Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 7/20 | 0.64 |
| ▸ | ROCK2 | O75116 | 8/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | CLK2 | P49760 | 1/20 | 0.41 |
| ▸ | BLK | P51451 | 1/20 | 0.41 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.41 |
| ▸ | STK3 | Q13188 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.41 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18056386 | 0.78 | ROCK1 (1.00) | ROCK1ROCK2CLK2BLKCSNK2A1 | |
| SCHEMBL20611956 | 0.77 | ROCK2 (0.44) | ROCK1ROCK2SMN1; SMN2POLBLMNA | |
| Trifluoroacetic Acid SCHEMBL18038124 | 0.74 | ROCK1 (0.89) | ROCK1ROCK2CLK2BLKCSNK2A1 | |
| SCHEMBL18792356 | 0.71 | ROCK2 (0.66) | ROCK1ROCK2SMN1; SMN2SLC2A1SLC2A3 | |
| SCHEMBL18792298 | 0.69 | ROCK2 (0.68) | ROCK1ROCK2SMN1; SMN2MEN1KMT2A | |
| SCHEMBL6153628 | 0.69 | ROCK1 (0.53) | ROCK1ROCK2KDM4EALDH1A1HSD17B10 | |
| SCHEMBL18038381 | 0.68 | ROCK1 (0.81) | ROCK1ROCK2CLK2BLKCSNK2A1 | |
| SCHEMBL6154211 | 0.68 | NOTUM (0.54) | ROCK1ROCK2KDM4EALDH1A1HSD17B10 | |
| SCHEMBL18792334 | 0.68 | ROCK2 (0.71) | ROCK1ROCK2CLK2BLKCSNK2A1 | |
| SCHEMBL6153927 | 0.68 | ALDH1A1 (0.52) | ROCK1ROCK2KDM4EALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180093978-A1 | INDAZOLYL THIADIAZOLAMINES AND RELATED COMPOUNDS FOR INHIBITION OF RHO-ASSOCIATED PROTEIN KINASE AND THE TREATMENT OF DISEASE | WILMINGTON TRUST, NATIONAL ASSOCIATION | 2018-04-05 | — | — | US | disclosed |
| US-9238815-B2 | Compositions and methods for inhibiting human host factors required for influenza virus replication | Icahn School of Medicine at Mounta Sinai (US) | 2016-01-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180093978-A1 | INDAZOLYL THIADIAZOLAMINES AND RELATED COMPOUNDS FOR INHIBITION OF RHO-ASSOCIATED PROTEIN KINASE AND THE TREATMENT OF DISEASE | ROCK1, ROCK2, CIT | ROCK1 1/4885ROCK2 2/4885KDM4E 653/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.