Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.34 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.34 |
| ▸ | ITGA2 | P17301 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | SDCBP | O00560 | 4/20 | 0.33 |
| ▸ | SDC2 | P34741 | 4/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | XIAP | P98170 | 1/20 | 0.33 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18766178 | 0.85 | SDCBP (0.42) | THRBALOX15MAPTSMN1; SMN2NPC1 | |
| SCHEMBL18794099 | 0.85 | SDCBP (0.42) | THRBALOX15MAPTSMN1; SMN2NPC1 | |
| SCHEMBL18766179 | 0.85 | SDCBP (0.42) | THRBALOX15MAPTSMN1; SMN2NPC1 | |
| SCHEMBL29676845 | 0.85 | SDCBP (0.42) | THRBALOX15MAPTSMN1; SMN2NPC1 | |
| SCHEMBL18793576 | 0.78 | AAK1 (0.40) | THRBMAPK1 | |
| SCHEMBL18793579 | 0.78 | AAK1 (0.40) | THRBMAPK1 | |
| SCHEMBL18793712 | 0.78 | AAK1 (0.40) | THRBMAPK1 | |
| SCHEMBL18793939 | 0.75 | MAPK1 (0.47) | MAPK1 | |
| SCHEMBL31592746 | 0.75 | MAPK1 (0.47) | MAPK1 | |
| SCHEMBL28526294 | 0.74 | ALDH1A1 (0.35) | THRBALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017068412-A1 | BENZOLACTAM COMPOUNDS AS PROTEIN KINASE INHIBITORS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2017-04-27 | — | — | WO | disclosed |