Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.51 |
| ▸ | PDE3B | Q13370 | 6/20 | 0.49 |
| ▸ | PDE3A | Q14432 | 6/20 | 0.49 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.45 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.45 |
| ▸ | PTGFR | P43088 | 1/20 | 0.45 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.45 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.45 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.45 |
| ▸ | IL4I1 | Q96RQ9 | 1/20 | 0.44 |
| ▸ | DHODH | Q02127 | 1/20 | 0.43 |
| ▸ | ALKBH3 | Q96Q83 | 1/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.42 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.41 |
| ▸ | CTRC | Q99895 | 1/20 | 0.41 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.41 |
| ▸ | NQO1 | P15559 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18796663 | 0.86 | PDE3B (0.64) | PDE10APDE3BPDE3AIL4I1 | |
| SCHEMBL18796704 | 0.81 | PDE3B (0.53) | PDE3BPDE3ATBXA2RPTGER4PTGFR | |
| SCHEMBL18796660 | 0.80 | PDE3B (0.55) | PDE3BPDE3AIL4I1 | |
| SCHEMBL18796726 | 0.77 | PDE3B (0.70) | PDE10APDE3BPDE3AIL4I1ALKBH3 | |
| SCHEMBL18796699 | 0.76 | PDE3B (0.54) | PDE3BPDE3ADHODH | |
| SCHEMBL16670764 | 0.76 | TSHR (0.63) | TBXA2RPTGER4PTGFRPTGER3PTGER2 | |
| SCHEMBL4431596 | 0.76 | KDM4E (0.45) | PDE10ATBXA2RPTGER4PTGFRPTGER3 | |
| SCHEMBL9592619 | 0.71 | PDE10A (0.55) | PDE10AALKBH3PTGDR2CTRCNQO1 | |
| SCHEMBL18796770 | 0.70 | PDE3B (0.56) | PDE3BPDE3ATBXA2RPTGFRPTGER3 | |
| SCHEMBL1149714 | 0.69 | CYP1A2 (0.52) | DHODH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017072796-A1 | 2-PYRIDONE BASED COMPOUNDS USEFUL AS POTENTIAL PHOSPHODIESTERASE3A (PDE3A)INHIBITORS AND A PROCESS FOR THE PREPARATION THEREOF | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2017-05-04 | — | — | WO | claimed |