Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 4/20 | 0.56 |
| ▸ | PDE3A | Q14432 | 4/20 | 0.56 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.44 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.43 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.42 |
| ▸ | PTGFR | P43088 | 1/20 | 0.42 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.42 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.42 |
| ▸ | PTGIR | P43119 | 1/20 | 0.42 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18796637 | 0.86 | PDE3B (0.76) | PDE3BPDE3AKDM4EL3MBTL1SMN1; SMN2 | |
| SCHEMBL18796691 | 0.85 | PDE3B (0.70) | PDE3BPDE3AGAAKDM4EL3MBTL1 | |
| SCHEMBL18796704 | 0.79 | PDE3B (0.53) | PDE3BPDE3AGAAPKMKDM4E | |
| SCHEMBL18796737 | 0.75 | PDE3B (0.71) | PDE3BPDE3AKDM4ESMN1; SMN2HPGD | |
| SCHEMBL18796699 | 0.75 | PDE3B (0.54) | PDE3BPDE3AGAAPKMKDM4E | |
| SCHEMBL18796660 | 0.70 | PDE3B (0.55) | PDE3BPDE3AGAAPKMKDM4E | |
| SCHEMBL18796682 | 0.70 | PDE10A (0.51) | PDE3BPDE3ATBXA2RPTGFRPTGER3 | |
| SCHEMBL5881957 | 0.70 | PTGS2 (0.49) | KDM4EL3MBTL1HPGDALDH1A1 | |
| SCHEMBL5881620 | 0.70 | PTPN5 (0.57) | GAAKDM4EL3MBTL1HPGDALDH1A1 | |
| SCHEMBL27853748 | 0.69 | ALDH1A1 (0.61) | GAAKDM4EKDM4CSMN1; SMN2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017072796-A1 | 2-PYRIDONE BASED COMPOUNDS USEFUL AS POTENTIAL PHOSPHODIESTERASE3A (PDE3A)INHIBITORS AND A PROCESS FOR THE PREPARATION THEREOF | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2017-05-04 | — | — | WO | claimed |