Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 17/20 | 0.59 |
| ▸ | MKNK2 | Q9HBH9 | 8/20 | 0.59 |
| ▸ | EIF4E | P06730 | 1/20 | 0.36 |
| ▸ | GSK3A | P49840 | 1/20 | 0.36 |
| ▸ | CDK9 | P50750 | 1/20 | 0.36 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.36 |
| ▸ | TAOK1 | Q7L7X3 | 1/20 | 0.36 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18786834 | 0.74 | MKNK1 (1.00) | MKNK1MKNK2EIF4E | |
| SCHEMBL18814801 | 0.72 | MKNK1 (0.54) | MKNK1MKNK2GSK3ACDK9CDK5 | |
| SCHEMBL18814767 | 0.71 | MKNK1 (0.53) | MKNK1MKNK2EIF4EEGFRERBB2 | |
| SCHEMBL18786885 | 0.71 | MKNK1 (0.68) | MKNK1MKNK2EIF4E | |
| SCHEMBL18797820 | 0.70 | MKNK1 (0.49) | MKNK1MKNK2EIF4EGSK3ACDK9 | |
| SCHEMBL18786890 | 0.70 | MKNK1 (0.61) | MKNK1MKNK2EIF4E | |
| SCHEMBL18786719 | 0.69 | MKNK1 (1.00) | MKNK1MKNK2EIF4E | |
| SCHEMBL18786622 | 0.69 | MKNK1 (0.59) | MKNK1MKNK2EIF4E | |
| SCHEMBL18797819 | 0.68 | MKNK1 (1.00) | MKNK1MKNK2EIF4E | |
| Hydrochloric Acid SCHEMBL28909496 | 0.68 | BTK (0.42) | MKNK1MKNK2EGFRERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3368530-A1 | ISOINDOLINE, AZAISOINDOLINE, DIHYDROINDENONE AND DIHYDROAZAINDENONE INHIBITORS OF MNK1 AND MNK2 | Effector Therapeutics Inc. (US) | 2018-09-05 | — | — | EP | disclosed |
| WO-2017075394-A1 | ISOINDOLINE, AZAISOINDOLINE, DIHYDROINDENONE AND DIHYDROAZAINDENONE INHIBITORS OF MNK1 AND MNK2 | EFFECTOR THERAPEUTICS, INC. (US) | 2017-05-04 | — | — | WO | disclosed |