Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 14/20 | 0.53 |
| ▸ | MKNK2 | Q9HBH9 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.38 |
| ▸ | EIF4E | P06730 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18815025 | 0.71 | MKNK1 (0.54) | MKNK1MKNK2EGFRERBB2EIF4E | |
| SCHEMBL18797844 | 0.71 | MKNK1 (0.59) | MKNK1MKNK2EGFRERBB2EIF4E | |
| SCHEMBL18786719 | 0.69 | MKNK1 (1.00) | MKNK1MKNK2EIF4E | |
| SCHEMBL18814801 | 0.67 | MKNK1 (0.54) | MKNK1MKNK2EGFRERBB2 | |
| SCHEMBL30062475 | 0.67 | MEN1 (0.67) | SMN1; SMN2EGFRMEN1KMT2ANPC1 | |
| SCHEMBL18786622 | 0.67 | MKNK1 (0.59) | MKNK1MKNK2EIF4E | |
| SCHEMBL18786706 | 0.67 | MKNK1 (1.00) | MKNK1MKNK2EIF4E | |
| SCHEMBL18786784 | 0.67 | MKNK1 (0.69) | MKNK1MKNK2EIF4E | |
| SCHEMBL18797824 | 0.67 | MKNK1 (0.54) | MKNK1MKNK2EGFRERBB2EIF4E | |
| SCHEMBL28243138 | 0.67 | MKNK1 (0.54) | MKNK1MKNK2EGFRERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017075394-A1 | ISOINDOLINE, AZAISOINDOLINE, DIHYDROINDENONE AND DIHYDROAZAINDENONE INHIBITORS OF MNK1 AND MNK2 | EFFECTOR THERAPEUTICS, INC. (US) | 2017-05-04 | — | — | WO | disclosed |