Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 11/20 | 0.54 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.45 |
| ▸ | KDR | P35968 | 2/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.36 |
| ▸ | GSK3A | P49840 | 1/20 | 0.34 |
| ▸ | CDK9 | P50750 | 1/20 | 0.34 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.34 |
| ▸ | TAOK1 | Q7L7X3 | 1/20 | 0.34 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.34 |
| ▸ | MPL | P40238 | 4/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18797844 | 0.72 | MKNK1 (0.59) | MKNK1MKNK2EGFRERBB2GSK3A | |
| SCHEMBL18815026 | 0.71 | MKNK1 (0.56) | MKNK1MKNK2KDREGFRERBB2 | |
| SCHEMBL18786719 | 0.70 | MKNK1 (1.00) | MKNK1MKNK2 | |
| SCHEMBL18814767 | 0.67 | MKNK1 (0.53) | MKNK1MKNK2EGFRERBB2 | |
| SCHEMBL14843891 | 0.67 | MKNK1 (0.49) | MKNK1MKNK2KDRGSK3ACDK9 | |
| SCHEMBL16144467 | 0.66 | ALDH1A1 (0.54) | MKNK1MKNK2KDREGFRERBB2 | |
| SCHEMBL4630887 | 0.66 | GSK3A (0.53) | MKNK1MKNK2KDRGSK3ACDK9 | |
| SCHEMBL18786614 | 0.66 | MKNK1 (1.00) | MKNK1MKNK2 | |
| SCHEMBL18786817 | 0.66 | MKNK1 (1.00) | MKNK1MKNK2MPL | |
| SCHEMBL28243161 | 0.65 | MKNK1 (0.55) | MKNK1MKNK2KDREGFRERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017075394-A1 | ISOINDOLINE, AZAISOINDOLINE, DIHYDROINDENONE AND DIHYDROAZAINDENONE INHIBITORS OF MNK1 AND MNK2 | EFFECTOR THERAPEUTICS, INC. (US) | 2017-05-04 | — | — | WO | disclosed |