Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EZH2 | Q15910 | 13/20 | 0.35 |
| ▸ | PRMT6 | Q96LA8 | 3/20 | 0.33 |
| ▸ | EED | O75530 | 3/20 | 0.31 |
| ▸ | RBBP4 | Q09028 | 3/20 | 0.31 |
| ▸ | SUZ12 | Q15022 | 3/20 | 0.31 |
| ▸ | AEBP2 | Q6ZN18 | 2/20 | 0.31 |
| ▸ | EZH1 | Q92800 | 3/20 | 0.31 |
| ▸ | RBBP7 | Q16576 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16549193 | 0.87 | EZH2 (0.43) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL21418328 | 0.82 | EZH2 (0.46) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL19391613 | 0.79 | EZH2 (0.38) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL19391398 | 0.79 | EZH2 (0.37) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL19430247 | 0.77 | PRMT6 (0.38) | PRMT6 | |
| SCHEMBL19430139 | 0.76 | PRMT6 (0.41) | PRMT6 | |
| SCHEMBL19430240 | 0.76 | PRMT6 (0.36) | PRMT6 | |
| SCHEMBL19430236 | 0.76 | PRMT1 (0.40) | PRMT6 | |
| SCHEMBL19430052 | 0.75 | PRMT6 (0.40) | PRMT6 | |
| SCHEMBL19430075 | 0.75 | PRMT6 (0.38) | PRMT6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9637472-B2 | Substituted 6,5-fused bicyclic heteroaryl compounds | Epizyme, Inc. (US) | 2017-05-02 | — | — | US | disclosed |