Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EZH2 | Q15910 | 18/20 | 0.37 |
| ▸ | EED | O75530 | 5/20 | 0.35 |
| ▸ | RBBP4 | Q09028 | 5/20 | 0.35 |
| ▸ | SUZ12 | Q15022 | 5/20 | 0.35 |
| ▸ | AEBP2 | Q6ZN18 | 4/20 | 0.35 |
| ▸ | RBBP7 | Q16576 | 1/20 | 0.34 |
| ▸ | EZH1 | Q92800 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19391613 | 0.91 | EZH2 (0.38) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL18800355 | 0.79 | EZH2 (0.35) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL21418320 | 0.74 | EZH2 (0.52) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL19620906 | 0.69 | EZH2 (0.52) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL22517696 | 0.68 | EZH2 (0.54) | EZH2EEDRBBP4SUZ12RBBP7 | |
| SCHEMBL20170350 | 0.66 | EZH2 (0.49) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL10254853 | 0.66 | EZH2 (0.75) | EZH2EEDRBBP4SUZ12RBBP7 | |
| SCHEMBL19391673 | 0.65 | EZH2 (0.70) | EZH2EEDRBBP4SUZ12RBBP7 | |
| SCHEMBL16549193 | 0.65 | EZH2 (0.43) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL20170154 | 0.65 | EZH2 (0.51) | EZH2EZH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2681216-B1 | SUBSTITUTED 6,5-FUSED BICYCLIC HETEROARYL COMPOUNDS | EPIZYME INC (US) | 2017-09-27 | — | — | EP | disclosed |