Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 10/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | FABP1 | P07148 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.37 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.36 |
| ▸ | SLC16A1 | P53985 | 1/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.36 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.36 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.36 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.36 |
| ▸ | F10 | P00742 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18800769 | 0.87 | ADORA2A (0.48) | BTKMAPK10TNK2 | |
| SCHEMBL18800492 | 0.84 | BTK (0.48) | BTKTNK2 | |
| SCHEMBL18800882 | 0.84 | BTK (0.42) | BTKNR1H2NR1H3TNK2 | |
| SCHEMBL18800775 | 0.84 | TNK2 (0.48) | BTKKMT2ALMNAGAAMAPK10 | |
| SCHEMBL18800616 | 0.83 | BTK (0.47) | BTKTNK2 | |
| SCHEMBL18800753 | 0.83 | BTK (0.49) | BTKTNK2 | |
| SCHEMBL18800641 | 0.83 | BTK (0.42) | BTKNR1H2NR1H3TNK2 | |
| SCHEMBL18800574 | 0.83 | BTK (0.42) | BTKNR1H2NR1H3TNK2 | |
| SCHEMBL18800748 | 0.83 | BTK (0.42) | BTKLMNAGAAMAPK10NR1H2 | |
| SCHEMBL18800463 | 0.82 | BTK (0.60) | BTKNR1H2NR1H3TNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2789615-B1 | Azaindazoles as Btk kinase modulators and use thereof | BRISTOL MYERS SQUIBB CO (US) | 2017-05-03 | — | — | EP | disclosed |