Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 12/20 | 0.47 |
| ▸ | TNK2 | Q07912 | 5/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18800492 | 0.99 | BTK (0.48) | BTKTNK2ADORA2AADORA1SCN9A | |
| SCHEMBL18800753 | 0.97 | BTK (0.49) | BTKTNK2ADORA2AADORA1SCN9A | |
| SCHEMBL18800564 | 0.94 | BTK (0.47) | BTKTNK2SCN9A | |
| SCHEMBL18800747 | 0.92 | KMT2A (0.46) | BTKTNK2ADORA2AADORA1 | |
| SCHEMBL16168177 | 0.90 | PARP10 (0.51) | BTKTNK2SCN9A | |
| SCHEMBL18800757 | 0.90 | TNK2 (0.49) | BTKTNK2SCN9A | |
| SCHEMBL18800635 | 0.89 | BTK (0.48) | BTKTNK2ADORA2AADORA1SCN9A | |
| SCHEMBL18800583 | 0.89 | BTK (0.43) | BTKTNK2SCN9A | |
| SCHEMBL18800775 | 0.89 | TNK2 (0.48) | BTKTNK2ADORA2AADORA1 | |
| SCHEMBL18800776 | 0.89 | BTK (0.49) | BTKTNK2SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2789615-B1 | Azaindazoles as Btk kinase modulators and use thereof | BRISTOL MYERS SQUIBB CO (US) | 2017-05-03 | — | — | EP | disclosed |