Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 16/20 | 0.61 |
| ▸ | ACE | P12821 | 8/20 | 0.61 |
| ▸ | MMEL1 | Q495T6 | 7/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16008239 | 0.88 | MME (0.80) | MMEACEMMEL1 | |
| SCHEMBL18598043 | 0.85 | MME (0.79) | MMEACEMMEL1 | |
| SCHEMBL16270268 | 0.84 | MME (0.69) | MMEACEMMEL1 | |
| SCHEMBL16008124 | 0.78 | MME (0.77) | MMEACEMMEL1 | |
| SCHEMBL16011808 | 0.78 | MME (0.77) | MMEACEMMEL1 | |
| SCHEMBL16011679 | 0.76 | MME (0.78) | MMEACEMMEL1 | |
| SCHEMBL16008688 | 0.76 | MME (0.78) | MMEACEMMEL1 | |
| SCHEMBL14890447 | 0.76 | MME (1.00) | MMEACEMMEL1 | |
| SCHEMBL18597868 | 0.76 | MME (1.00) | MMEACEMMEL1 | |
| SCHEMBL14890588 | 0.75 | MME (0.70) | MMEACEMMEL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2964616-B1 | NEPRILYSIN INHIBITORS | THERAVANCE BIOPHARMA R&D IP LLC (US) | 2017-05-03 | — | — | EP | disclosed |