Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.50 |
| ▸ | PARP1 | P09874 | 1/20 | 0.50 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.37 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 3/20 | 0.35 |
| ▸ | HTR2C | P28335 | 3/20 | 0.35 |
| ▸ | HTR2B | P41595 | 3/20 | 0.35 |
| ▸ | KIF11 | P52732 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.33 |
| ▸ | TDP2 | O95551 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12894753 | 0.80 | PARP10 (0.58) | PARP10PARP1PARP11HTR2AHTR2C | |
| SCHEMBL4991137 | 0.75 | PARP10 (0.56) | PARP10PARP1PARP11S1PR1HTR2A | |
| SCHEMBL3534887 | 0.74 | PARP10 (0.51) | PARP10PARP1PARP11KIF11MEN1 | |
| SCHEMBL19978083 | 0.74 | PARP10 (0.46) | PARP10PARP1PARP11MEN1ALDH1A1 | |
| SCHEMBL25089741 | 0.73 | PARP1 (0.53) | PARP10PARP1HTR2AHTR2CHTR2B | |
| SCHEMBL5775632 | 0.72 | MEN1 (0.44) | PARP10PARP1HTR2AHTR2CHTR2B | |
| SCHEMBL1735429 | 0.72 | PARP10 (0.60) | PARP10PARP1PARP11S1PR1HTR2A | |
| SCHEMBL30038782 | 0.72 | PARP10 (0.60) | PARP10PARP1PARP11S1PR1HTR2A | |
| SCHEMBL30953872 | 0.70 | PARP10 (0.54) | PARP10PARP1PARP11HTR2AHTR2C | |
| SCHEMBL429558 | 0.70 | PARP10 (0.54) | PARP10PARP1PARP11HTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3272749-A1 | AMINO-SUBSTITUTED IMIDAZO[1,2-A]PYRIDINECARBOXAMIDES AND THEIR USE AS STIMULATORS OF SOLUBLE GUANYLATE CYCLASE | Bayer Pharma Aktiengesellschaft (DE) | 2018-01-24 | — | — | EP | disclosed |
| EP-2914594-B1 | AMINO-SUBSTITUTED IMIDAZO[1,2-A]PYRIDINECARBOXAMIDES AND THEIR USE | Bayer Pharma AG (DE) | 2017-05-03 | — | — | EP | disclosed |