Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.44 |
| ▸ | METAP2 | P50579 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 4/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | APEX1 | P27695 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18801336 | 0.91 | LMNA (0.44) | ALDH1A1METAP2POLBRAB9ANPSR1 | |
| SCHEMBL1649341 | 0.86 | METAP2 (0.47) | ALDH1A1METAP2RAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL18801057 | 0.82 | METAP2 (0.42) | ALDH1A1METAP2RAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL18801150 | 0.81 | METAP2 (0.48) | METAP2POLB | |
| SCHEMBL18801061 | 0.81 | METAP2 (0.43) | ALDH1A1METAP2POLBRAB9AKMT2A | |
| SCHEMBL1648786 | 0.80 | METAP2 (0.47) | ALDH1A1METAP2RAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL18801306 | 0.79 | METAP2 (0.56) | ALDH1A1METAP2POLBRAB9AKMT2A | |
| SCHEMBL18801277 | 0.78 | CYP2C9 (0.42) | ALDH1A1METAP2KMT2ALMNA | |
| SCHEMBL18801304 | 0.78 | METAP2 (0.49) | ALDH1A1METAP2KMT2AHPGDLMNA | |
| SCHEMBL1648250 | 0.78 | METAP2 (0.43) | METAP2RAB9AKMT2AHTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2486004-B1 | SULPHONE COMPOUNDS FOR USE IN THE TREATMENT OF OBESITY | ZAFGEN INC (US) | 2017-05-03 | — | — | EP | disclosed |