Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | METAP2 | P50579 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.32 |
| ▸ | SLC37A4 | O43826 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.31 |
| ▸ | NAT1 | P18440 | 2/20 | 0.31 |
| ▸ | PPARG | P37231 | 2/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.30 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.30 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.30 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.30 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18801115 | 0.92 | KMT2A (0.39) | KMT2AMETAP2MAPTHTTL3MBTL1 | |
| SCHEMBL18801122 | 0.92 | KMT2A (0.39) | KMT2AMETAP2MAPTHTTL3MBTL1 | |
| SCHEMBL18801413 | 0.89 | KDM4E (0.37) | KMT2AMETAP2MAPTHTTALDH1A1 | |
| SCHEMBL18801173 | 0.88 | ALDH1A1 (0.41) | KMT2AMAPTL3MBTL1ALDH1A1MEN1 | |
| SCHEMBL18801148 | 0.88 | KMT2A (0.39) | KMT2AMETAP2MAPTHTTL3MBTL1 | |
| SCHEMBL1649341 | 0.87 | METAP2 (0.47) | KMT2AMETAP2L3MBTL1SLC37A4ALDH1A1 | |
| SCHEMBL18801052 | 0.85 | KMT2A (0.37) | KMT2AMETAP2SLC37A4MEN1POLB | |
| SCHEMBL18801357 | 0.84 | CYP1A1 (0.39) | KMT2AMETAP2HTTALDH1A1MEN1 | |
| SCHEMBL18801102 | 0.83 | PDK2 (0.38) | KMT2AMETAP2PPARGPPARA | |
| SCHEMBL18801117 | 0.81 | KMT2A (0.44) | KMT2AMETAP2MAPTHTTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2486004-B1 | SULPHONE COMPOUNDS FOR USE IN THE TREATMENT OF OBESITY | ZAFGEN INC (US) | 2017-05-03 | — | — | EP | disclosed |