Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 4/20 | 0.48 |
| ▸ | TUBB4A | P04350 | 8/20 | 0.38 |
| ▸ | TUBB | P07437 | 8/20 | 0.38 |
| ▸ | TUBA3C | P0DPH7 | 8/20 | 0.38 |
| ▸ | TUBA1B | P68363 | 8/20 | 0.38 |
| ▸ | TUBA4A | P68366 | 8/20 | 0.38 |
| ▸ | TUBB4B | P68371 | 8/20 | 0.38 |
| ▸ | TUBB3 | Q13509 | 8/20 | 0.38 |
| ▸ | TUBB2A | Q13885 | 8/20 | 0.38 |
| ▸ | TUBB8 | Q3ZCM7 | 8/20 | 0.38 |
| ▸ | TUBA3E | Q6PEY2 | 8/20 | 0.38 |
| ▸ | TUBA1A | Q71U36 | 8/20 | 0.38 |
| ▸ | TUBA1C | Q9BQE3 | 8/20 | 0.38 |
| ▸ | TUBB6 | Q9BUF5 | 8/20 | 0.38 |
| ▸ | TUBB2B | Q9BVA1 | 8/20 | 0.38 |
| ▸ | TUBB1 | Q9H4B7 | 8/20 | 0.38 |
| ▸ | FABP4 | P15090 | 1/20 | 0.37 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 2/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1648265 | 0.92 | METAP2 (0.44) | METAP2TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL18801077 | 0.90 | METAP2 (0.44) | METAP2TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL18801327 | 0.89 | PPARG (0.41) | METAP2TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL18801296 | 0.89 | METAP2 (0.38) | METAP2TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL1649262 | 0.88 | METAP2 (0.40) | METAP2TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL18801087 | 0.88 | METAP2 (0.47) | METAP2TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL18801419 | 0.88 | METAP2 (0.45) | METAP2TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL1648294 | 0.86 | METAP2 (0.38) | METAP2TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL18801299 | 0.85 | METAP2 (0.38) | METAP2FABP4FABP5PPARGKDM4E | |
| SCHEMBL18801303 | 0.85 | METAP2 (0.35) | METAP2PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2486004-B1 | SULPHONE COMPOUNDS FOR USE IN THE TREATMENT OF OBESITY | ZAFGEN INC (US) | 2017-05-03 | — | — | EP | disclosed |