Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 4/20 | 0.38 |
| ▸ | TSHR | P16473 | 4/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | PPARG | P37231 | 2/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | TUBB4A | P04350 | 3/20 | 0.33 |
| ▸ | TUBB | P07437 | 3/20 | 0.33 |
| ▸ | TUBA3C | P0DPH7 | 3/20 | 0.33 |
| ▸ | TUBA1B | P68363 | 3/20 | 0.33 |
| ▸ | TUBA4A | P68366 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18801327 | 0.91 | PPARG (0.41) | METAP2TDP1PPARGALDH1A1CYP3A4 | |
| SCHEMBL1648265 | 0.88 | METAP2 (0.44) | METAP2TDP1PPARGALDH1A1CYP3A4 | |
| SCHEMBL18801147 | 0.86 | METAP2 (0.48) | METAP2TDP1PPARGALDH1A1CYP3A4 | |
| SCHEMBL18801446 | 0.82 | METAP2 (0.35) | METAP2TSHRPPARGCYP3A4CYP1A2 | |
| SCHEMBL1650137 | 0.82 | METAP2 (0.37) | METAP2TSHRTDP1L3MBTL1PPARG | |
| SCHEMBL18801296 | 0.80 | METAP2 (0.38) | METAP2TSHRPPARGMAPK1CYP3A4 | |
| SCHEMBL18801422 | 0.80 | ALDH1A1 (0.41) | TSHRTDP1L3MBTL1PPARGALDH1A1 | |
| SCHEMBL18801334 | 0.80 | EGFR (0.38) | METAP2PPARGEGFRALDH1A1SMN1; SMN2 | |
| SCHEMBL18801077 | 0.77 | METAP2 (0.44) | METAP2TSHRPPARGALDH1A1CYP3A4 | |
| SCHEMBL18801299 | 0.76 | METAP2 (0.38) | METAP2PPARGEGFRALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2486004-A2 | SULPHONE COMPOUNDS AND METHODS OF MAKING AND USING SAME | Zafgen Corporation (US) | 2012-08-15 | — | — | EP | disclosed |
| WO-2011044506-A2 | SULPHONE COMPOUNDS AND METHODS OF MAKING AND USING SAME | ZAFGEN CORPORATION (US) | 2011-04-14 | — | — | WO | disclosed |