Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K11 | Q16584 | 2/20 | 0.36 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.33 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.33 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.32 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.32 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.32 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.32 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.32 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.32 |
| ▸ | MARK3 | P27448 | 1/20 | 0.31 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.31 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.31 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | XBP1 | P17861 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16946150 | 0.78 | MAP3K11 (0.38) | MAP3K11PDK2PDK4ATAD2MARK3 | |
| SCHEMBL2707978 | 0.73 | HPGD (0.37) | MARK3FGFR1ALDH1A1LMNAMAPT | |
| SCHEMBL16941382 | 0.72 | BRD4 (0.46) | MAP3K11BMPR1BTGFBR1ACVR1MARK3 | |
| SCHEMBL25093202 | 0.70 | MAPK14 (0.40) | MAP3K11 | |
| SCHEMBL2756587 | 0.69 | PSEN1 (0.39) | MEN1ALDH1A1LMNAMAPTKMT2A | |
| SCHEMBL2707211 | 0.69 | PSEN1 (0.41) | ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL26448707 | 0.69 | MAPK14 (0.39) | MAP3K11PDE3BPDE3A | |
| SCHEMBL15457685 | 0.68 | PDK2 (0.52) | PDK2PDK4BMPR1BBMPR1ATGFBR1 | |
| SCHEMBL13340900 | 0.68 | BRD4 (0.35) | — | |
| SCHEMBL13072753 | 0.66 | ATAD2 (0.42) | PDK2PDK4BMPR1BBMPR1ATGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2882738-B1 | NEW ANTIBACTERIAL COMPOUNDS | JANSSEN SCIENCES IRELAND UC (IE) | 2017-05-31 | — | — | EP | disclosed |
| EP-2882739-B1 | NEW ANTIBACTERIAL COMPOUNDS | JANSSEN SCIENCES IRELAND UC (IE) | 2017-05-03 | — | — | EP | disclosed |