Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 9/20 | 0.64 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.55 |
| ▸ | DNM1 | Q05193 | 2/20 | 0.53 |
| ▸ | CASP2 | P42575 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | SELP | P16109 | 1/20 | 0.50 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.49 |
| ▸ | NAAA | Q02083 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10634427 | 0.92 | FAAH (0.50) | FAAHHSP90AA1DNM1CASP2MEN1 | |
| SCHEMBL10628189 | 0.89 | FAAH (0.46) | FAAHHSP90AA1DNM1SELP | |
| SCHEMBL10630200 | 0.85 | TSHR (0.43) | FAAHCASP2 | |
| SCHEMBL20263725 | 0.84 | FAAH (0.44) | FAAHHSP90AA1DNM1MEN1KMT2A | |
| SCHEMBL6520442 | 0.83 | FAAH (0.61) | FAAHHSP90AA1DNM1CASP2SELP | |
| SCHEMBL15468338 | 0.83 | — | — | |
| SCHEMBL7747959 | 0.82 | FAAH (0.67) | FAAHHSP90AA1DNM1CASP2MEN1 | |
| SCHEMBL9126413 | 0.82 | FAAH (0.67) | FAAHHSP90AA1DNM1CASP2MEN1 | |
| SCHEMBL20263735 | 0.82 | FAAH (0.41) | FAAHDNM1MEN1KMT2A | |
| SCHEMBL14661992 | 0.82 | FAAH (0.67) | FAAHHSP90AA1DNM1CASP2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110106241-A1 | COMPOSITIONS AND METHODS FOR INHIBITING SPHINGOSINE KINASE | UNIVERSITY OF VIRGINIA PATENT FOUNDATION | 2011-05-05 | — | — | US | disclosed |
| WO-2009146112-A1 | COMPOSITIONS AND METHODS FOR INHIBITING SPHINGOSINE KINASE | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2009-12-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110106241-A1 | COMPOSITIONS AND METHODS FOR INHIBITING SPHINGOSINE KINASE | SPHK2, SPHK1, S1PR2 | FAAH 891/4885HSP90AA1 3031/4885DNM1 574/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.